1887

Abstract

Summary

The molecular features of bovine viral diarrhoea virus (BVDV), a member of the genus currently classified in the , were examined for characteristics resembling those of the family. Like flaviviruses, BVDV possesses a single-stranded RNA genome (approx. 4.3 × 10 ) deficient in a 3′ poly(A) tract. This RNA has a single open reading frame spanning the length of the genome in the viral RNA sense (positive polarity), implying an expression strategy involving the processing of a precursor polyprotein. With the exception of several short but significant stretches of identical amino acids within two non-structural proteins, no extended regions of nucleotide or amino acid sequence homology between BVDV and representatives of three serological subgroups of mosquito-borne flaviviruses were noted. However, comparison of the organization of protein-coding domains along the genomes and the hydropathic profiles of amino acid sequences revealed pronounced similarities. It is proposed that , of which BVDV is the prototype member, should no longer be grouped in the family, but rather be considered a genus of non-arthropod-borne viruses within the .

Keyword(s): BVDV , Flaviviridae and Pestivirus
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1988-10-01
2021-10-19
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