1887

Abstract

Summary

In mice, intravenous inoculation of relatively avirulent strains of herpes simplex virus [e.g. PC, a mutant of strain CL(101), deficient in thymidine kinase] produced infection in the adrenal gland and mid-spinal cord followed by hind limb paralysis without death. Male mice were less susceptible to paralysis than female mice. Castration of male mice before inoculation increased their susceptibility to that of female animals; treatment with testosterone reversed this change. The differences in susceptibility to paralysis in the various categories of animal were not reflected in differences in growth of virus in the adrenal gland or spinal cord.

Keyword(s): androgens , HSV-1 and paralysis
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-9-2461
1987-09-01
2021-08-03
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/9/JV0680092461.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-9-2461&mimeType=html&fmt=ahah

References

  1. Blyth W. A., Harbour D. A., Hill T. J. 1984; Pathogenesis of zosteriform spread of herpes simplex virus in the mouse. Journal of General Virology 65:1477–1486
    [Google Scholar]
  2. Castro J. E. 1974; Orchidectomy and the immune response. II.Response of orchidectomized mice to antigens. Proceedings of the Royal Society Series B 185:437–451
    [Google Scholar]
  3. Deanesley R., Parkes A. S. 1937; Multiple activities of androgenic compounds. Quarterly Journal of Experimental Physiology 26:393–402
    [Google Scholar]
  4. Dubbs D. R., Kit S. 1964; Mutant strains of herpes simplex deficient in thymidine kinase-inducing activity. Virology 22:493–502
    [Google Scholar]
  5. Field H. J., Darby G. 1980; Pathogenicity in mice of strains of herpes simplex virus which are resistant to Acyclovir in vitroand in vivo . Antimicrobial Agents and Chemotherapy 17:209–216
    [Google Scholar]
  6. Hall N. R., Goldstein A. L. 1984; Endocrine regulation of host immunity. The role of steroids and thymosin. In Immune Modulation Agents and Their Mechanisms pp 533–563 Fenichel R. L., Chirigos M. A. Edited by New York: Marcel Dekker;
    [Google Scholar]
  7. Hill T. J., Blyth W. A., Harbour D. A. 1978; Trauma to the skin causes recurrence of herpes simplex in the mouse. Journal of General Virology 39:21–28
    [Google Scholar]
  8. Hill T. J., Yirrell D. L., Blyth W. A. 1986; Infection of the adrenal gland as a route to the central nervous system after viraemia with herpes simplex virus in the mouse. Journal of General Virology 67:309–320
    [Google Scholar]
  9. Knoblich A., Gortz J., Harle-Grupp V., Falke D. 1983; Kinetics and genetics of herpes simplex virus- induced antibody formation in mice. Infection and Immunity 39:15–23
    [Google Scholar]
  10. Lahita R. G. 1984; Sex hormones and immunity. In Basic and Clinical Immunology pp 288–292 Stites D. B., Stobo J. D., Fudenberg H. H., Wells J. V. Edited by Los Altos: Lang Medical Publications;
    [Google Scholar]
  11. Nash A. A., Phelan J., Gell P. G. H., Wildy P. 1981; Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity. Immunology 43:363–369
    [Google Scholar]
  12. Townsend J. J. 1981; The demyelinating effect of corneal HSV infections in normal and nude (athymic) mice. Journal of Neurological Sciences 50:435–441
    [Google Scholar]
  13. Townsend J. J., Baringer J. R. 1979; Morphology of central nervous system disease in immunosuppressed mice after peripheral herpes simplex virus inoculation. Laboratory Investigation 40:178–182
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-9-2461
Loading
/content/journal/jgv/10.1099/0022-1317-68-9-2461
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error