Several species of small animals were inoculated at birth or as adults with blood components from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders, or with the human immunodeficiency virus (HIV). No ill effects were noted in rats, hamsters, guinea-pigs, rabbits or musk shrews. Mice inoculated with clinical specimens had a significant incidence of mortality as compared with control groups (18·7% against 5·9%, P < 0·025). Mice receiving HIV showed an increase in mortality, but it was not statistically significant. Infection of the animals by HIV could not be detected by virological or immunological studies. We concluded that none of these animal species provided a useful model for evaluating HIV infection.
AlterH. J.,
EichbergJ. W.,
MasurH.,
SaxingerW. C.,
GalloR.,
MacherA. M.,
LaneH. C.,
FauciA. S.1984; Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science 226:549–552
FrancisD. P.,
FeorinoP. M.,
BrodersonJ. R.,
McclureH. M.,
GetchellJ. P.,
McgrathC. R.,
SwensonB.,
McdougalJ. S.,
PalmerE. L.,
HarrisonA. K.,
Barre-SinoussiF.,
ChermannJ-C.,
MontagnierL.,
CurranJ. W.,
CabradillaD. C.,
KalaynaramanV. S.1984; Infection of chimpanzees with lymphadenopathy- associated virus. Lancet ii:1276–1277
FultzP. N.,
McclureH. M.,
SwensonR. B.,
McgrathC. R.,
BrodieA.,
GetchellJ. P.,
JewsonF. C.,
AndersonL. D. C.,
BrodersonJ. R.,
FrancisD. P.1986; Persistent infection of chimpanzees with human T- lymphotropic virus type III lymphadenopathy-associated virus: a potential model for acquired immunodeficiency syndrome. Journal of Virology 58:116–124
GajdusekD. C.,
AmyxH. L.,
GibbsC. L.JrAsherD. M.,
Rodgers-JohnsonP.,
EpsteinL. G.,
SarinP. S.,
GalloR. C.JrMaluishA.,
LoA.,
GildonR. v.,
MontagnierL.,
MildvanD.1985; Infection of chimpanzees by human T-lymphotropic retroviruses in brain and other tissues from AIDS patients. Lancet i:55–56
HoffmanAD.,
BanapourB.,
LevyJ. A.1985; Characterization of the AIDS-associated retroviruses, reverse transcriptase, and optimal conditions for its detection in virions. Virology 147:326–335
KaminskyL. S.,
MchughT.,
StitesD.,
VolberdingP.,
HenleG.,
HenleW.,
LevyJ. A.1985; High prevalence of antibodies to AIDS-associated retroviruses (ARV) in acquired immune deficiency syndrome and related conditions and not in other disease states. Proceedings of the National Academy of Sciences U.S.A.: 825535–5539
LevyJ. A.,
HoffmanA. D.,
KramerS. M.,
LandisJ. A.,
ShimabukuruJ. M.,
OshiroL. S.1984; Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science 225:840–842
LevyJ. A.,
ShimabukuroJ.,
MchughI.,
CasavantC.,
StitesD.,
OshiroL. S.1985a; AIDS-aSSOCiated retroviruses (ARV) can productively infect other cells besides human T helper cells. Virology 147:441–448
LevyJ. A.,
ShimabukuroI.,
HollanderH.,
MillsJ.,
KaminskyL.1985b; Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurologic symptoms. Lancet ii:586–588
LevyJ. A.,
Cheng-MayerC.,
DinaD.,
LuciwP.1986; Replication of AIDS-associated retrovirus (ARV-2) in human and animal fibroblast cells transfected with a molecular clone of the virus. Science 232:998–1001
PanL-Z.,
Cheng-MayerC.,
LevyJ. A.1987; Patterns of antibody response in individuals infected with the human immunodeficiency virus. Journal of Infectious Diseases 155:475–481