We examined the specificity of BALB/c cytotoxic T (T) cells for respiratory syncytial virus (RSV) components, using recombinant vaccinia viruses (VV) coding for several individual RSV proteins. We found that immunization with the different VVs yielded the following T memory cell populations: high levels of RSV-specific T cells were induced with the fusion protein VV, but low levels were induced with VV, coding for the RSV nucleoprotein. T cell recognition of attachment glycoprotein, part of the matrix molecule or 1A internal protein was poor. While high levels of fusion protein-specific T cells were induced by the fusion protein VV, they showed poor cross-reactivity between the A2 and 8/60 RSV strains compared with T cells primed by RSV infection.


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