@article{mbs:/content/journal/jgv/10.1099/0022-1317-68-7-1993, author = "Svensson, Lennart and Sheshberadaran, Hooshmand and Vesikari, Timo and Norrby, Erling and Wadell, Göran", title = "Immune Response to Rotavirus Polypeptides after Vaccination with Heterologous Rotavirus Vaccines (RIT 4237, RRV-1)", journal= "Journal of General Virology", year = "1987", volume = "68", number = "7", pages = "1993-1999", doi = "https://doi.org/10.1099/0022-1317-68-7-1993", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-7-1993", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "rotavirus", keywords = "vaccine", keywords = "immune response", abstract = "SUMMARY The antibody response to individual rotavirus polypeptides after vaccination with live attenuated heterologous rotavirus vaccines was studied with a radioimmunopreci-pitation assay (RIPA). Following vaccination with bovine rotavirus strain RIT 4237 and rhesus monkey rotavirus strain RRV-1, an antibody response was demonstrated mainly against the inner capsid polypeptides VP2 and VP6 and to a lesser extent against VP3/VP4. There was no qualitative difference between the vaccines in the antibody response; both vaccines induced antibodies against the same polypeptides. Quantitatively the antibody response to RRV-1 was somewhat stronger. All prevaccination sera contained by RIPA low levels of rotavirus antibodies. The effect of these antibodies on the ‘take’ of the vaccines is discussed.", }