%0 Journal Article %A Spriggs, Melanie K. %A Johnson, Philip R. %A Collins, Peter L. %T Sequence Analysis of the Matrix Protein Gene of Human Parainfluenza Virus Type 3: Extensive Sequence Homology among Paramyxoviruses %D 1987 %J Journal of General Virology, %V 68 %N 5 %P 1491-1497 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-68-5-1491 %K sequence analysis %K matrix protein %K paramyxovirus evolution %I Microbiology Society, %X SUMMARY The sequences of the human parainfluenza virus type 3 (PIV3) matrix (M) mRNA [1150 nucleotides exclusive of poly(A)] and predicted M protein (353 amino acids) were determined by sequence analysis of cloned cDNA and viral genomic RNA. The gene- end sequence of the M gene dilfered from the semi-conserved gene-end sequence of the other PIV3 genes by an apparent insertion of eight nucleotides. The PIV3 M protein shared high sequence homology with Sendai virus and moderate homology with measles virus and canine distemper virus. Statistical analysis of the available sequences showed that the M protein was the most highly conserved parainfluenza viral protein. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-5-1491