1887

Abstract

SUMMARY

Methylation of Marek’s disease virus serotype 1 (MDV1) DNA in both productively and latently infected cells was examined by restriction endonuclease analyses with the isoschizomeric pair I and I The latent MDV1 DNA in T-lymphoblastoid cell lines established from chicken T-lymphomas was considerably methylated, whereas methylation of the virus DNA sequences was not detected in productively infected cells.

Keyword(s): MD cell lines , MDV and methylation
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-5-1485
1987-05-01
2021-10-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/5/JV0680051485.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-5-1485&mimeType=html&fmt=ahah

References

  1. Akiyama Y., Kato S. 1974; Two cell lines from lymphomas of Marek’s disease. Biken Journal 17:105–116
    [Google Scholar]
  2. Desrosiers R. C., Mulder C., Fleckenstein B. 1979; Methylation of herpesvirus saimiri DNA in lymphoid tumor cell lines. Proceedings of the National Academy of Sciences, U.S.A 76:3839–3843
    [Google Scholar]
  3. Doerfler W. 1981; DNA methylation - a regulatory signal in eukaryotic gene expression. Journal of General Virology 57:1–20
    [Google Scholar]
  4. Doerfler W. 1983; DNA methylation and gene activity. Annual Review of Biochemistry 52:93–124
    [Google Scholar]
  5. Fukuchi K., Sudo M., Lee Y.-s., Tanaka A., Nonoyama M. 1984; Structure of Marek’s disease virus DNA: detailed restriction enzyme map. Journal of Virology 51:102–109
    [Google Scholar]
  6. Hirai K., Ikuta T., Kitamoto N., Kato S. 1981; Latency of herpesvirus of turkey and Marek’s disease virus genomes in a chicken T-lymphoblastoid cell line. Journal of General Virology 53:133–143
    [Google Scholar]
  7. Hirai K., Honma H., Ikuta K., Kato S. 1984a; Genetic relatedness of virulent and avirulent strains of Marek’s disease virus. Archives of Virology 79:293–298
    [Google Scholar]
  8. Hirai K., Ikuta K., Nakajima K., Kato K., Mikami T. 1984b; Possible functions of Marek’s disease virus DNA fragment that might be related to the virulency and to the cross-reaction with herpesvirus of turkeys. In Proceedings of the International Symposium on Marek’s Disease pp. 30–50 Calnek B. W., Spencer J. L. Edited by Kennet Square: American Association of Avian Pathologists;
    [Google Scholar]
  9. Hirai K., Nakajima K., Ikuta K., Kirisawa R., Kawakami Y., Mikami T., Kato S. 1986a; Similarities and dissimilarities in the structure and expression of viral genomes of various virus strains immunologically related to Marek’s disease virus. Archives of Virology 89:113–130
    [Google Scholar]
  10. Hirai K., Maotani K., Ikuta K., Yasue H., Ishibashi M., Kato S. 1986b; Chromosomal sites for Marek’s disease virus DNA in two chicken lymphoblastoid cell lines MDCC-MSB1 and MDCC-RP1. Virology 152:256–261
    [Google Scholar]
  11. Ikuta K., Ueda S., Kato S., Hirai K. 1983; Most virus-specific polypeptides in cells productively infected with Marek’s disease virus or herpesvirus of turkeys possess cross-reactive determinants. Journal of General Virology 64:961–965
    [Google Scholar]
  12. Ikuta K., Nakajima K., Naito M., Ann S. H., Ueda S., Kato S., Hirai K. 1985; Indentification of Marek’s disease virus-specific antigens in Marek’s disease lymphoblastoid cell lines using monoclonal antibody against virus-specific phosphorylated polypeptides. International Journal of Cancer 35:257–264
    [Google Scholar]
  13. Kaschka-Dierich C., Nazerian K., Thomssen R. 1979; Intracellular state of Marek’s disease virus DNA in two tumour-derived chicken cell lines. Journal of General Virology 44:271–280
    [Google Scholar]
  14. Larocca D., Clough W. 1982; Hypomethylation of Epstein-Barr virus DNA in the nonproducer B-cell line EBR. Journal of Virology 43:1120–1131
    [Google Scholar]
  15. Maotani K., Kanamori A., Ikuta K., Ueda S., Kato S., Hirai K. 1986; Amplification of a tandem direct repeat within inverted repeats of Marek’s disease virus DNA during serial in vitro passage. Journal of Virology 58:657–660
    [Google Scholar]
  16. Naito M., Nakajima K., Iwa N., Ono K., Yoshida I., Konobe T., Ikuta K., Ueda S., Kato S., Hirai K. 1986; Demonstration of a Marek’s disease virus-specific antigen in tumor lesions of chickens with Marek’s disease using monoclonal antibody against a virus phosphorylated protein. Avian Pathology 15:503–510
    [Google Scholar]
  17. Nazerian K., Lee L. F. 1974; Deoxyribonucleic acid of Marek’s disease virus in a lymphoblastoid cell line from Marek’s disease tumours. Journal of General Virology 25:317–321
    [Google Scholar]
  18. Powell P. c., Payne L. N., Frazier J. A., Rennie M. 1974; T-lymphoblastoid cell lines from Marek’s disease lymphomas. Nature; London: 25179–81
    [Google Scholar]
  19. Ross L. J. N., Delorbe W., Varmus H. E., Bishop J. M., Brahic M., Haase A. 1981; Persistence and expression of Marek’s disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization. Journal of General Virology 57:285–296
    [Google Scholar]
  20. Rziha H.-J., Bauer B. 1982; Circular forms of viral DNA in Marek’s disease virus-transformed lymphoblastoid cells. Archives of Virology 72:211–216
    [Google Scholar]
  21. Silver S., Tanaka A., Nonoyama M. 1979; Transcription of Marek’s disease virus genome in a non-productive chicken lymphoblastoid cell line. Virology 93:127–133
    [Google Scholar]
  22. Tanaka A., Silver S., Nonoyama M. 1978; Biochemical evidence of the non-integrated status of Marek’s disease virus DNA in virus-transformed lymphoblastoid cells of chicken. Virology 88:19–24
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-5-1485
Loading
/content/journal/jgv/10.1099/0022-1317-68-5-1485
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error