%0 Journal Article %A Ren, Guo %A En-Hua, Tang %A Hong, Wang %A Xiao-Feng, Yang %A Ming-Ying, Liu %A Hong-Xing, Qin %A Qi-Han, Li %A Jun-Ying, Zhuang %A Kai-Ming, Liu %T Preliminary Studies on Antigenic Variation of Poliovirus Using Neutralizing Monoclonal Antibodies %D 1987 %J Journal of General Virology, %V 68 %N 4 %P 989-994 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-68-4-989 %K poliovirus %K monoclonal antibodies %K antigenic variation %I Microbiology Society, %X Summary Cross-neutralization assays were done using 85 strains of poliovirus type 1 with five groups of monoclonal antibodies. These strains were classified into 10 subgroups which had marked differences in antigenicity. Subgroups P1-2 (28%) and P1-5 (43%) were dominant and have been epidemic in China in recent years. These two subgroups were antigenically different from the Sabin-1 strain, but according to their responses to one group of monoclonal antibodies they had antigenic epitopes in common with the Mahoney and Brunhilde strains. Similarly, 91 strains of type 3 poliovirus were classified into six subgroups with another five groups of monoclonal antibodies. The results showed that strain P3/Yunnan/2/84, which was isolated from cases of poliomyelitis in a local epidemic in the Yunnan province of China in 1984, and strain P3/Finland/23127/84, which was isolated in Finland in 1984, were both antigenically different from the Sabin-3 strain and the reference virulent strain. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-4-989