RT Journal Article SR Electronic(1) A1 Mohri, Shirou A1 Handa, Sumio A1 Tateishi, JunYR 1987 T1 Lack of Effect of Thymus and Spleen on the Incubation Period of Creutzfeldt-Jakob Disease in Mice JF Journal of General Virology, VO 68 IS 4 SP 1187 OP 1189 DO https://doi.org/10.1099/0022-1317-68-4-1187 PB Microbiology Society, SN 1465-2099, AB SUMMARY Genetically athymic and asplenic (Lasat), athymic (Nude), asplenic (Dh) or normal littermate (Hetero) mice with a BALB/c genetic background were injected either intracerebrally or intraperitoneally with a 1% or 10% homogenate of mouse brains infected with the Fukuoka 1 strain of the Creutzfeldt-Jakob disease (CJD) agent. As there were no significant differences in incubation periods among the five groups (Lasat, Nude, Dh, Hetero and BALB/c) inoculated with the same dilution, via the same route, it was concluded that cell-mediated immunity dependent on the thymus plays no significant role in host defence against the CJD agent, and the spleen, a critical site of agent replication, is apparently not an obligatory source from which infection spreads to the central nervous system., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-4-1187