1887

Abstract

SUMMARY

Genetically athymic and asplenic (Lasat), athymic (Nude), asplenic (Dh) or normal littermate (Hetero) mice with a BALB/c genetic background were injected either intracerebrally or intraperitoneally with a 1% or 10% homogenate of mouse brains infected with the Fukuoka 1 strain of the Creutzfeldt-Jakob disease (CJD) agent. As there were no significant differences in incubation periods among the five groups (Lasat, Nude, Dh, Hetero and BALB/c) inoculated with the same dilution, via the same route, it was concluded that cell-mediated immunity dependent on the thymus plays no significant role in host defence against the CJD agent, and the spleen, a critical site of agent replication, is apparently not an obligatory source from which infection spreads to the central nervous system.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-4-1187
1987-04-01
2022-01-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/4/JV0680041187.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-4-1187&mimeType=html&fmt=ahah

References

  1. Bruce M. E. 1985; Agent replication dynamics in a long incubation period model of mouse scrapie. Journal of General Virology 66:2517–2522
    [Google Scholar]
  2. Clarke M. C., Haig D. A. 1971; Multiplication of scrapie agent in mouse spleen. Research in Veterinary Science 12:195–197
    [Google Scholar]
  3. Collis S. C., Kimberlin R. H. 1985; Long-term persistence of scrapie infection in mouse spleens in the absence of clinical disease. FEMS Microbiology tetters 29:111–114
    [Google Scholar]
  4. Dickinson A. G., Fraser H. 1972; Scrapie: effect of Dh gene on incubation period of extraneurally injected agent. Heredity 29:91–93
    [Google Scholar]
  5. Dickinson A. G., Outram G. W. 1979; The scrapie replication-site hypothesis and its implications for pathogenesis. In Slow Transmissible Diseases of the Nervous System 2 pp 13–31 Prusiner S. B., Hadlow W. J. Edited by New York: Academic Press;
    [Google Scholar]
  6. Fraser H., Dickinson A. G. 1970; Pathogenesis of scrapie in the mouse: the role of the spleen. Nature; London: 226462–463
    [Google Scholar]
  7. Fraser H., Dickinson A. G. 1978; Studies of the lymphoreticular system in the pathogenesis of scrapie: the role of spleen and thymus. Journal of Comparative Pathology 88:563–573
    [Google Scholar]
  8. Gajdusek D. C. 1977; Unconventional viruses and the origin and disappearance of kuru. Science 197:943–960
    [Google Scholar]
  9. Kimberlin R. H., Walker C. A. 1977; Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34:295–304
    [Google Scholar]
  10. Kimberlin R. H., Walker C. A. 1979; Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. Journal of Comparative Pathology 89:551–562
    [Google Scholar]
  11. Kimberlin R. H., Walker C. A. 1986; Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. Journal of General Virology 67:255–263
    [Google Scholar]
  12. Kingsbury D. T., Smeltzer D. A., Gibbs C. J. Jr Gajdusek D. C. 1981; Evidence for normal cell-mediated immunity in scrapie-infected mice. Infection and Immunity 32:1176–1180
    [Google Scholar]
  13. Kingsbury D. T., Kasper K. C., Stites D. P., Watson J. D., Hogan R. N., Prusiner S. B. 1983; Genetic Control of scrapie and Creutzfeldt-Jakob disease in mice. Journal of Immunology 131:491–496
    [Google Scholar]
  14. Kuroda Y., Gibbs C. J. Jr Amyx H. L., Gajdusek D. C. 1983; Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. Infection and Immunity 41:154–161
    [Google Scholar]
  15. Mcfarlin D. E., Raff M. C., Simpson E., Nehlsen S. H. 1971; Scrapie in immunologically deficient mice. Nature; London: 233336
    [Google Scholar]
  16. Machado E. A., Lozzio B. B., Lair S. v. 1976; Characterization of hereditarily athymic-asplenic mice. In Immuno-aspects of the Spleen pp 215–226 Battisto J. R., Streilein J. W. Edited by Amsterdam: Elsevier/North-Holland;
    [Google Scholar]
  17. Manuelidis E. E., Gorgacz E. J., Manuelidis L. 1978; Transmission of Creutzfeldt-Jakob disease with scrapielike syndromes to mice. Nature; London: 271778–779
    [Google Scholar]
  18. Tateishi J., Ohta M., Koga M., Sato Y., Kuroiwa Y. 1979; Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents. Annals of Neurology 5:581–584
    [Google Scholar]
  19. Tateishi J., Sato Y., Koga M., Doi H., Ohta M. 1980; Experimental transmission of human subacute spongiform encephalopathy to small rodents. Acta neuropathologica 51:127–134
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-4-1187
Loading
/content/journal/jgv/10.1099/0022-1317-68-4-1187
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error