Relationship between the Replication of Hepatitis B Virus and the Localization of Virus Nucleocapsid Antigen (HBcAg) in Hepatocytes

References

1. Alberti A., Tremolada F., Fadttovich G., Bortolotti F., Realdi G. 1983; Virus replication and liver disease in chronic hepatitis B virus infection. Digestive Disease and Sciences 28:962–966
   [Google Scholar]
2. Blum H. E., Haase A. T., Vyas G. N. 1984; Molecular pathogenesis of hepatitis B virus infection. Simultaneous detection of viral DNA and antigen in paraffin embedded liver sections. Lancet ii:771–774
   [Google Scholar]
3. Bonino F., Hoyer B., Nelson J., Engle R., Verme G., Gerin J. 1981; Hepatitis B virus in the sera of HBsAg carriers. A marker of active hepatitis B virus replication in the liver. Hepatology 1:386–391
   [Google Scholar]
4. Burrell C. J., Gowans E. J., Jilbert A. R., Lake J. R., Marmion B. p. 1982; Hepatitis B virus DNA detection by in situ cytohybridization. Implication for viral replication strategy and pathogenesis of chronic hepatitis. Hepatology 2:85s–95s
   [Google Scholar]
5. Burrell C. J., Gowans E. J., Marmion B. P. 1985; High levels of cytoplasmic hepatitis B core antigen as reliable marker of HBV DNA replication. Lancet i:454–455
   [Google Scholar]
6. Dienstag J. L. 1984; Immunologic mechanisms in chronic viral hepatitis. In Viral Hepatitis and Liver Disease pp 135–166 Vyas G. N., Dienstag J. L., Hoofnagle J. H. Edited by Orlando: Grune & Stratton;
   [Google Scholar]
7. Gowans E. J., Burrell C. J., Jilbert A. R., Marmion B. P. 1983; Patterns of single- and double-stranded hepatitis B virus DNA and viral antigen accumulation in infected liver cells. Journal of General Virology 64:1229–1239
   [Google Scholar]
8. Gudat F., Bianchi L., Sonnabend W., The1L G., Aenishaenslin W., Stalder A. 1975; Pattern of core and surface expression in liver tissue reflects state of specific response in hepatitis B. Laboratory Investigation 32:1–9
   [Google Scholar]
9. Hadziyannis S. J., Lieberman H. M., Karvountzis G. G., Shafritz D. A. 1983; Analysis of liver disease, nuclear HBcAg, viral replication, and hepatitis B virus DNA in liver and serum of HBeAg vs. anti-HBe positive carriers of hepatitis B virus. Hepatology 3:656–662
   [Google Scholar]
10. Hsu S. M., Raine L., Fanger H. 1981; A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. American Journal of Clinical Pathology 75:734–738
    [Google Scholar]
11. Huang S. N., Neurath A. R. 1979; Immunohistologic demonstration of hepatitis B viral antigens in liver with reference to its significance in liver injury. Laboratory Investigation 40:1–17
    [Google Scholar]
12. Imai M., Tachibana F. C., Moritsugu Y., Miyakawa Y., Mayumi M. 1976; Hepatitis B antigen-associated deoxyribonucleic acid and e antigen/anti-e system. Infection and Immunity 14:631–635
    [Google Scholar]
13. Kanno A., Ohori H., Mastuda K., Nakayama H., Miyazaki Y., Ishii M., Suzuki H., Ohtuski M., Goto Y. 1987; Clinical and virological signification of HBeAg subtypes (HBeAg/1 and HBeAg/2): HBeAg/2 is an indicator of active viral replication in HBsAg carriers. Hepatology 7: in press
    [Google Scholar]
14. Mackay P., Lees J., Murray K. 1981; The conversion of hepatitis B core antigen synthesized in E. coli into e antigen. Journal of Medical Virology 8:237–243
    [Google Scholar]
15. Negro F., Berninger M., Chiabege E., Gugliotta A., Bussolati G., Actis C. G., Rizzetto M., Bonino F. 1985; Detection of HBV-DNA by in situ hybridization using a biotin-labelled probe. Journal of Medical Virology 15:373–382
    [Google Scholar]
16. Nordenfelt E., Kjellen L. 1975; Dane particles, DNA polymerase and e-antigen in two distinct categories of hepatitis B antigen carriers. Intervirology 5:225–232
    [Google Scholar]
17. Ohori H., Onodera S. 1979; Demonstration of hepatitis B e antigen (HBeAg) in association with intact Dane particles. Journal of General Virology 43:423–427
    [Google Scholar]
18. Ohori H., Yamada E., Tateda A., Ishida N. 1980; Prevalence of Williams e, antigen in comparison with e₂antigen in hepatitis B antigen carriers and patients in a hemodialysis unit. Journal of Medical Virology 6:6174
    [Google Scholar]
19. Review of the International Group 1977; Acute and chronic hepatitis revisited. Lancet ii:395–398
    [Google Scholar]
20. Scott J., Hadchouel M., Hery C., Yvart J., Tiollais P., Brechot C. 1983; Detection of hepatitis B virus DNA in serum by simple spot hybridization technique. Comparison with results for other viral markers. Hepatology 3:279–284
    [Google Scholar]
21. Summers J., Mason W. S. 1982; Replication of the genome of a hepatitis B like virus by reverse transcription of an RNA intermediate. Cell 29:403–415
    [Google Scholar]
22. Trevisan A., Realdi G., Alberti A., Ongaro G., Parnaro E., Meliconi R. 1982; Core antigen-Specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B. Gastroenterology 82:218–222
    [Google Scholar]
23. Yamada G., Nakane P. K. 1977; Hepatitis B core and surface antigen in liver tissue. Light and electron microscopic localization by the peroxidase-labelled antibody method, laboratory Investigation 36:649–659
    [Google Scholar]