Evidence for Antigenic Stability of Tick-borne Encephalitis Virus by the Analysis of Natural Isolates Free

Abstract

SUMMARY

Strains of tick-borne encephalitis (TBE) virus isolated from ticks in natural foci in Austria were compared to strains isolated from the same foci 14 years previously. Comparative peptide mapping of the envelope (E) glycoproteins as well as analysis of the antigenic structure of the E proteins by the use of 14 monoclonal antibodies defining different epitopes did not provide evidence for antigenic variation. The same also holds true for isolates from a probably newly established natural focus in Western Austria. These results confirm previous data by showing that under natural ecological conditions TBE virus is quite stable and does not undergo major antigenic changes.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-3-859
1987-03-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/3/JV0680030859.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-3-859&mimeType=html&fmt=ahah

References

  1. Castle E., Nowark T., Leidner U., Wengler G., Wengler G. 1985; Sequence analysis of the viral core protein and the membrane associated proteins VI and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins. Virology 145:227–236
    [Google Scholar]
  2. Cleveland D. W., Fischer S. G., Kirschner M. W., Lammli U. K. 1977; Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. Journal of Biological Chemistry 252:1102–1106
    [Google Scholar]
  3. Clewley J. P., Bishop D. H. L., Kang C.-Y., Coffin J., Schnitzlein W. N., Reichman M. E., Shope R. E. 1977; Oligonucleotide fingerprints of RNA species obtained from Rhabdoviruses belonging to the vesicular stomatitis virus subgroup. Journal of Virology 23:152–166
    [Google Scholar]
  4. Dalgarno L., Trent D. W., Strauss J. H., Rice C. M. 1986; Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins. Journal of Molecular Biology 187:309–323
    [Google Scholar]
  5. Heinz F. X., Kunz C. 1981; Homogeneity of the structural glycoprotein from European isolates of tick-borne encephalitis virus: comparison with other flaviviruses. Journal of General Virology 57:263–274
    [Google Scholar]
  6. Heinz F. X., Kunz C. 1982; Molecular epidemiology of tick-borne encephalitis virus: peptide mapping of large non-structural proteins of European isolates and comparison with other flaviviruses. Journal of General Virology 62:271–285
    [Google Scholar]
  7. Heinz F. X., Tuma W., Kunz C. 1981; Antigenic and immunogenic properties of defined physical forms of tickborne encephalitis virus structural proteins. Infection and Immunity 33:250–257
    [Google Scholar]
  8. Heinz F. X., Berger R., Tuma W., Kunz C. 1983; A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology 126:525–537
    [Google Scholar]
  9. Holland J., Spindler K., Horodyski F., Grabau E., Nichol S., Vandepol S. 1982; Rapid evolution of RNA genomes. Science 215:1577–1585
    [Google Scholar]
  10. Kozak M. 1983; Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiological Reviews 47:1–45
    [Google Scholar]
  11. Kunz CH., Heinz F. X., Hofmann H. 1980; Immunogenicity and reactogenicity of a highly purified vaccine against tick-borne encephalitis. Journal of Medical Virology 6:103–109
    [Google Scholar]
  12. Laemmli U. K., Favre M. 1973; Maturation of the head of bacteriophage T4.1. DNA packaging events. Journal of Molecular Biology 80:575–599
    [Google Scholar]
  13. Reanney D. C. 1982; The evolution of RNA viruses. Annual Review of Microbiology 36:47–73
    [Google Scholar]
  14. Rice C. M., Lenches E. M., Eddy S. R., Shin S. J., Sheets R. L., Strauss J. H. 1985; Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science 229:726–733
    [Google Scholar]
  15. Shope R. E. 1980; Significance of togaviruses: an overview of diseases caused by togaviruses in man and in domestic and wild vertebrate animals. In The Togaviruses: Biology, Structure, Replication pp 47–82 Schlesinger R. W. Edited by New York: Academic Press;
    [Google Scholar]
  16. Stephenson J. R., Lee J. M., Wilton-Smith P. D. 1984; Antigenic variation among members of the tick-borne encephalitis complex. Journal of General Virology 65:81–89
    [Google Scholar]
  17. Wengler G., Castle E., Leidner U., Nowak T., Wengler G. 1985; Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene. Virology 147:264–274
    [Google Scholar]
  18. Westaway E. G., Brinton M. A., Gaidamovich S. Y., Horzinek M. C., Igarashi A., Kääriäinen L., Lvov D. K., Porterfield J. S., Russell P. K., Trent D. W. 1985; Flaviviridae. Intervirology 24:183–192
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-3-859
Loading
/content/journal/jgv/10.1099/0022-1317-68-3-859
Loading

Data & Media loading...

Most cited Most Cited RSS feed