1887

Abstract

SUMMARY

Mice inoculated intravenously with 10 to 100 μg trehalose-6,6 ′-dimycolate in an oil- in-water emulsion (TDM emulsion) acquired high resistance to intranasal infection by influenza virus at 7 to 14 days, but not at 1 day, after treatment. Mice inoculated with an oil-in-water emulsion without TDM (control emulsion) did not resist infection. The activity of the reticuloendothelial system of mice inoculated with TDM emulsion or control emulsion was greatly stimulated 1 day and 14 days after treatment. Interferon production in response to influenza virus was augmented in lung and serum of TDM emulsion-treated mice. The augmented interferon production was greatly diminished in the TDM emulsion-treated mice by treatment with anti-Thy-1.2 monoclonal antibody. Production of haemagglutination-inhibiting antibody in the TDM emulsion- treated or control emulsion-treated mice was higher than that in untreated mice, although no difference was observed between the TDM emulsion-treated and control emulsion-treated mice. On the other hand, TDM emulsion treatment of mice did not influence the appearance of antibody-producing cells, nor the activity of natural killer cells in the mice. The enhanced resistance of mice was diminished by inoculating anti- interferon-α/ serum before influenza virus infection. No detectable interferon activity was observed in lung and blood of mice inoculated with anti-interferon-α/ serum prior to influenza virus infection. These results suggest that the augmented early interferon production in T-lymphocytes of TDM emulsion-treated mice in response to influenza virus may play an important role in the enhanced resistance.

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1987-03-01
2021-10-20
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References

  1. Adam A., Devys M., Souvannavong V., Lefrancier P., Choay J., Lederer E. 1976; Correlation of structure and adjuvant activity of V-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), its derivatives and analogues. Biochemical and Biophysical Research Communications 72:339–346
    [Google Scholar]
  2. Bancroft G. J., Shellam G. R., Chalmer J. E. 1981; Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. Journal of Immunology 126:988–994
    [Google Scholar]
  3. Barksdale L., Kim K. S. 1977 Mycobacterium. Bacteriological Reviews 41:217–372
    [Google Scholar]
  4. Bekierkunst A. 1968; Acute granulomatous response produced in mice by trehalose-6,6ʹ-dimycolate. Journal of Bacteriology 96:958–961
    [Google Scholar]
  5. Bekierkunst A., Levij I. S., Yarkoni E., Vilkas E., Adam A., Lederer E. 1969; Granuloma formation induced in mice by chemically defined mycobacterial fractions. Journal of Bacteriology 100:95–102
    [Google Scholar]
  6. Bekierkunst A., Yarkoni E., Flechner L, Vilkas E., Lederer E. 1971; Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions. Infection and Immunity 4:256–263
    [Google Scholar]
  7. Chedid L., Parant M., Parant F., Lefrancier P., Choay J., Lederer E. 1977; Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (V-acetyl-muramyl-l-alanyl-d-isoglutamine) and several analogs. Proceedings of the National Academy of Sciences U.S.A.: 742089–2093
    [Google Scholar]
  8. Cummings N. P., Pabst M. J., Johnston R. B. 1980; Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. Journal of Experimental Medicine 152:1659–1669
    [Google Scholar]
  9. Cunningham A. J., Szenberg A. 1968; Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology 14:599–600
    [Google Scholar]
  10. Djeu J. Y., Heinbaugh J. A., Holden H. T., Herberman R. B. 1979; Role of macrophages in the augmentation of mouse natural killer cell activity by poly I :C and interferon. Journal of Immunology 122:182–188
    [Google Scholar]
  11. Ellouz F., Adam A., Ciorbaru R., Lederer E. 1974; Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochemical and Biophysical Research Communications 59:1317–1325
    [Google Scholar]
  12. Goren M. B., Bernnan P. J. 1979; Mycobacterial lipids: chemistry and biologic activities. In Tuberculosis pp 132–134 Youmans G. P. Edited by Philadelphia: W. B. Saunders;
    [Google Scholar]
  13. Gresser I., Tovey M. G., Bandu M. T., Maury C., Broutyboye D. 1976a; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. Journal of Experimental Medicine 144:1305–1315
    [Google Scholar]
  14. Gresser I., Tovey M. G., Maury C., Bandu M. T. 1976b; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses. Journal of Experimental Medicine 144:1316–1323
    [Google Scholar]
  15. Hashimoto Y., Sudo H. 1971; Evaluation of cell damage in immune reactions by release of radioactivity from 3H-uridine labeled cells. Gann 62:139–143
    [Google Scholar]
  16. Kawade Y. 1980; An analysis of neutralization reaction of interferon by antibody: a proposal on the expression of neutralization titer. Journal of Interferon Research 1:61–70
    [Google Scholar]
  17. Kirchner H., Engler H., Zawatzky R., Schindler L. 1982; Role of natural killer cells and of interferon in natural resistance against virus infections. Advances in Experimental Medicine and Biology 155:785–797
    [Google Scholar]
  18. Kohl S., Harmon M. W. 1983; Human neonatal leukocyte interferon production and natural killer cytotoxicity in response to herpes simplex virus. Journal of Interferon Research 3:461–463
    [Google Scholar]
  19. Kusumoto S., Tarumi Y., Ikenaka K., Shiba T. 1976; Chemical synthesis of A-acetylmuramyl peptides with partial structures of bacterial cell wall and their analogs in relation to immunoadjuvant activities. Bulletin of the Chemical Society of Japan 49:533–539
    [Google Scholar]
  20. Matsumoto K., Ogawa H., Nagase O., Kusama T., Azuma I. 1981; Stimulation of nonspecific host resistance to infection induced by muramyl dipeptides. Microbiology and Immunology 25:1047–1058
    [Google Scholar]
  21. Oehler J.r., Herberman R. B. 1978; Natural cell-mediated cytotoxicity in rats. III. Effects of immunopharmacologic treatment on natural reactivity and on reactivity augmented by polyinosinic- polycytidylic acid. International Journal of Cancer 21:221–229
    [Google Scholar]
  22. Oehler J. R., Lindsay L. R., Nunn M. E., Holden H. T., Herberman R. B. 1978; Natural cell-mediated cytotoxicity in rats. II In vivo augmentation of NK-cell activity. International Journal of Cancer 21:210–220
    [Google Scholar]
  23. Ohara T., Shimmyo Y., Sekikawa I., Morikawa K., Sumikawa E. 1957; Studies on the cord factor, with special reference to its immunological properties. Japanese Journal of Tuberculosis 5:128–143
    [Google Scholar]
  24. Ojo E., Haller O., Wigzell H. 1978; Corynebacterium parvum-induced peritoneal exudate cells with rapid cytolytic activity against tumour cells are non-phagocytic cells with characteristics of natural killer cells. Scandinavian Journal of Immunology 8:215–222
    [Google Scholar]
  25. Potter M. R., Moore M. 1980; The effect of BCG stimulation on natural cytotoxicity in the rat. Immunology 39:427–434
    [Google Scholar]
  26. Rivière Y., Gresser L, Guillon J. C., Tovey M. G. 1977; Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. Proceedings of the National Academy of Sciences U.S.A.: 742135–2139
    [Google Scholar]
  27. Sakuma T., Suenaga T., Yoshida I., Azuma M. 1983; Mechanisms of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection. Infection and Immunity 42:567–573
    [Google Scholar]
  28. Sakuma T., Azuma M., Yoshida I. 1984; Effect of IV-acetyl-muramyl-l-alanyl-d-isoglutamine on interferon production in mice by Newcastle disease virus. Journal of General Virology 65:999–1003
    [Google Scholar]
  29. Santoli D., Trinchieri G., Koprowski H. 1978; Cell-mediated cytotoxicity against virus-infected target cells in humans. II. Interferon induction and activation of natural killer cells. Journal of Immunology 121:532–538
    [Google Scholar]
  30. Sever J. L. 1962; Application of a microtechnique to viral serological investigations. Journal of Immunology 88:320–329
    [Google Scholar]
  31. Shellam G. R., Allan J. E., Papadimitriou J. M. 1981; Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proceedings of the National Academy of Sciences U.S.A.: 785104–5108
    [Google Scholar]
  32. Suenaga T., Okuyama T., Yoshida I., Azuma M. 1978; Effect of Mycobacterium tuberculosis BCG infection on the resistance of mice to ectromelia virus infection: participation of interferon in enhanced resistance. Infection and Immunity 20:312–314
    [Google Scholar]
  33. Tanaka A., Nagao S., Nagao R., Kotani S., Shiba T., Kusumoto S. 1979; Stimulation of the reticuloendothelial system of mice by muramyl dipeptide. Infection and Immunity 24:302–307
    [Google Scholar]
  34. Tracey D. E. 1979; The requirement for macrophages in the augmentation of natural killer cell activity by BCG. Journal of Immunology 123:840–845
    [Google Scholar]
  35. Tsukui K. 1977; Influenza virus-induced interferon production in mouse spleen cell culture : T cells as the main producer. Cellular Immunology 32:243–251
    [Google Scholar]
  36. Welsh R. M. 1981; Natural cell-mediated immunity during viral infections. Current Topics in Microbiology and Immunology 92:83–106
    [Google Scholar]
  37. Wolfe S. A., Tracey D. E. 1976; Induction of ‘natural killer’ cells by BCG. Nature; London: 262584–586
    [Google Scholar]
  38. Wolfe S. A., Tracey D. E., Henney C. S. 1977; BCG-induced murine effector cells. II. Characterization of natural killer cells in peritoneal exudates. Journal of Immunology 119:1152–1158
    [Google Scholar]
  39. Yamamoto K., Kakinuma M., Kato K., Okuyama H., Azuma I. 1980; Relationship of anti-tuberculous protection to lung granuloma produced by intravenous injection of synthetic 6-O-mycoloyl-N-acetylmuramyl-l-alanyl-d-isoglutamine with or without specific antigens. Immunology 40:557–564
    [Google Scholar]
  40. Yarkoni E., Bekierkunst A. 1976; Nonspecific resistance against infection with Salmonella typhi and Salmonella typhimurium induced in mice by cord factor (trehalose-6,6ʹ-dimycolate) and its analogues. Infection and Immunity 14:1125–1129
    [Google Scholar]
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