1887

Abstract

SUMMARY

The effect of prostaglandins (PGs) of the A series (A and dimethyl PGA), E, D, F and PGI (prostacyclin) and of inhibitors of PG synthesis (aspirin and indomethacin) on the pathogenicity of vaccinia virus was studied in BALB/c mice. PGs of the A series, D and F conferred little or no protection to mice against the lethal effects of vaccinia virus. Mice treated with PGE showed a dramatic increase in mortality after viral infection. However, when mice were treated with PGI, their survival was greatly enhanced. Mice treated with aspirin and indomethacin showed a marked increase in mortality. Increased mortality correlated with higher virus yields in target tissues (spleen) and with inhibition of antibody response, whereas the increase in survival correlated with lower virus yields and with normal antibody responses. The significance of our findings is that PGI can block the outcome of the disease caused by vaccinia virus whereas other PGs and their inhibitors not only worsen the disease, but may activate and enhance viral infections through immune suppression.

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1987-02-01
2021-10-21
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