1887

Abstract

SUMMARY

Type D retroviruses have recently been shown to induce a wasting syndrome with associated lymphadenopathy, thymic atrophy and transient decreased peripheral blood lymphocyte blastogenic responsiveness in juvenile macaque monkeys. The replication of D/New England virus was assessed in various lymphocyte subpopulations to determine the possible pathogenesis of the immune dysfunction induced by this virus. While D/New England did not replicate in cultured T lymphocytes or induce any demonstrable dysfunction of T cells , it did grow in the cells of the B lymphocyte lineage. D/New England growth occurred in African Burkitt’s lymphoma and pre-B cell lines, but not in Epstein-Barr virus-transformed normal B lymphocytes. The infection of a restricted B lymphocyte population by this primate type D retrovirus may play a role in the aetiology of the immune abnormalities which it induces.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-2-573
1987-02-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/2/JV0680020573.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-2-573&mimeType=html&fmt=ahah

References

  1. Calvert J. E., Maruyama S., Tedder T. F., Webb C. F., Cooper M. D. 1984; Cellular events in the differentiation of antibody secreting cells. Seminars in Hematology 21:226–243
    [Google Scholar]
  2. Chopra H. C., Mason M. M. 1970; A new virus in a spontaneous mammary tumor of a rhesus monkey. Cancer Research 30:2081–2086
    [Google Scholar]
  3. Dalgleish A., Beverley P. C. L., Clapham P. R., Crawford D. H., Greaves M. F., Weiss R. A. 1984; The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature; London: 312763–767
    [Google Scholar]
  4. Daniel M. D., King N. W., Letvin N. L., Hunt R. D., Sehgal P. K., Desrosiers R. C. 1984; A new type D retrovirus isolated from macaques with an immunodeficiency syndrome. Science 223:602–605
    [Google Scholar]
  5. Desrosiers R., Daniel M. D., Butler C. V., Schmidt D. K., Letvin N. L., King N. W., Barker C. S., Hunter E. 1985; Retrovirus D/New England and its relation to Mason-Pfizer monkey virus. Journal of Virology 54:552–560
    [Google Scholar]
  6. Fine D. L., Landon J. C., Pienta R. J., Kubicek M. T., Valerio M. G., Loeb W. F., Chopra H. C. 1975; Responses of infant rhesus monkeys to inoculation with Mason-Pfizer monkey virus materials. Journal of the National Cancer Institute 54:651–656
    [Google Scholar]
  7. Fingeroth J. D., Weis J. M., Tedder T. F., Strominger J. L., Biro P. A., Fearon D. T. 1984; Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proceedings of the National Academy of Sciences, U.S.A 81:4510–4514
    [Google Scholar]
  8. Kannagi M., Yetz J. M., Letvin N. L. 1985; In vitro growth characteristics of simian T-lymphocyte virus type III. Proceedings of the National Academy of Sciences, U.S.A 82:7053–7057
    [Google Scholar]
  9. Klatzmann D., Champagne E., Chamaret S., Gruest J., Guetard D., Hercend T., Gluckman J. -C., Montagnier L. 1984; T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature; London: 312767–768
    [Google Scholar]
  10. Letvin N. L., Daniel M. D., Sehgal P. K., Chalifoux L. V., King N. W., Hunt R. D., Aldrich W. R., Holley K., Schmidt D. K., Desrosiers R. C. 1984; Experimental infection of rhesus monkeys with type D retrovirus. Journal of Virology 52:683–686
    [Google Scholar]
  11. Marx P. A., Maul D. H., Osborn K. G., Lerche N. W., Moody P., Lowenstine L. J., Henrickson R. V., Arthur L. O., Gravell M., London W. T., Sever J. L., Levy J. A., Munn R. J., Gardner M. B. 1984; Simian AIDS: isolation of a type D retrovirus and disease transmission. Science 223:1083–1086
    [Google Scholar]
  12. Marx P. A., Osborn K. G., Maul D. H., Lerche N. W., Lowenstine L. J., Kluge J. D., Zaiss C. P., Henrickson R. V., Shiigi S. M., Wilson B. J., Malley A., Olson L. C., Arthur L. O., Gilden R. V., Barker C. S., Hunter E., Munn R. J., Bryant M. L., Gardner M. B. 1985; Isolation of a new serotype of SAIDS type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. Journal of Virology 56:571–578
    [Google Scholar]
  13. Nadler L. M., Stashenko P., Hardy R., Van agthoven A., Terhorst C., Schlossman S. F. 1981; Characterization of a human B cell-specific antigen (B2) distinct from B1. Journal of Immunology 126:1941–1947
    [Google Scholar]
  14. Nadler L. M., Anderson K. C., Marti G., Bates M., Park E., Daley J. F., Schlossman S. F. 1983; B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. Journal of Immunology 131:244–250
    [Google Scholar]
  15. Nilsson K., Klein G. 1982; Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt’s lymphoma. Advances in Cancer Research 37:319–380
    [Google Scholar]
  16. Stromberg K., Benveniste R. E., Arthur L. O., Rabin H., Giddens W. E. JR Ochs H. D., Morton W. R., Tsai C. 1984; Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis. Science 224:289–292
    [Google Scholar]
  17. Tedder T. F., Clement L. T., Cooper M.D. 1985; Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. Journal of Immunology 134:2983–2988
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-2-573
Loading
/content/journal/jgv/10.1099/0022-1317-68-2-573
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error