@article{mbs:/content/journal/jgv/10.1099/0022-1317-68-2-433, author = "Wraith, David C. and Vessey, Angela E. and Askonas, Brigitte A.", title = "Purified Influenza Virus Nucleoprotein Protects Mice from Lethal Infection", journal= "Journal of General Virology", year = "1987", volume = "68", number = "2", pages = "433-440", doi = "https://doi.org/10.1099/0022-1317-68-2-433", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-2-433", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "cytotoxic T cells", keywords = "influenza A virus", keywords = "nucleoprotein", abstract = "SUMMARY Local administration of nucleoprotein purified from X31 (H3N2) influenza A virus primed for A virus cross-reactive cytotoxic T cells and resulted in substantial protection (75 %) of mice from a lethal challenge with the heterologous mouse-adapted A/PR/8/34 (H1N1) virus. By following the course of a lethal virus challenge we found that nucleoprotein priming did not prevent virus infection but rather aided recovery. Nucleoprotein-primed mice suffered initial symptoms of infection, i.e. weight loss and surface temperature changes, but started to recover after approximately 7 days. We suggest that such heterotypic protection can be attributed to priming of A virus crossreactive cytotoxic T cells.", }