1887

Abstract

Summary

Poliovirus-infected HeLa cells increased their permeability to monovalent ions from the third hour post-infection. At that time infected cells lost their content of potassium ions as measured by efflux of the potassium analogue Rb. The rate of release of Rb from cells increased as infection proceeded, and was not sensitive to ouabain or quinidine, inhibitors of the Na/K ATPase and Ca-induced K release system, respectively. The leakage of Rb was only slightly sensitive to furosemide, and inhibitor of the Na/K/Cl cotransport system, suggesting that the mechanism of release involved an increased passive permeability of the cell membrane. The calcium content or its efflux did not vary significantly in the infected cells. Neither were there alterations in the intracellular pH throughout infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-2-335
1987-02-01
2019-11-13
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-2-335
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error