Poliovirus-infected HeLa cells increased their permeability to monovalent ions from the third hour post-infection. At that time infected cells lost their content of potassium ions as measured by efflux of the potassium analogue Rb. The rate of release of Rb from cells increased as infection proceeded, and was not sensitive to ouabain or quinidine, inhibitors of the Na/K ATPase and Ca-induced K release system, respectively. The leakage of Rb was only slightly sensitive to furosemide, and inhibitor of the Na/K/Cl cotransport system, suggesting that the mechanism of release involved an increased passive permeability of the cell membrane. The calcium content or its efflux did not vary significantly in the infected cells. Neither were there alterations in the intracellular pH throughout infection.


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