RT Journal Article SR Electronic(1) A1 Street, Alasdair J. A1 Griffin, Beverly E.YR 1987 T1 Immunological Variation in the ‘Common Region’ of the T Antigens of Polyoma Virus JF Journal of General Virology, VO 68 IS 12 SP 3153 OP 3164 DO https://doi.org/10.1099/0022-1317-68-12-3153 PB Microbiology Society, SN 1465-2099, AB SUMMARY Characterization of a series of mouse monoclonal antibodies (designated αPy C21 to 26) against the region common to the large, middle and small T antigens of polyoma virus has revealed immunological diversities among the N termini of these antigens. Four of the antibodies (αPy C21 to 24) appeared to recognize all the T antigens present in lytically infected cells, but two of them (αPy C25, 26) failed to immunoprecipitate small T antigen either from 35S- or 32P-labelled cells and recognized only a subset of middle and large T antigens. None of the antibodies recognized the protein kinase activity normally associated with middle T antigen or the 60K mol. wt. antigen-related protein observed in polyoma virus lytically infected or transformed cells. The possible immunodominance of the N termini of the early gene products (as well as VP1) in the natural host of polyoma virus and the observed antigenic heterogeneity are considered., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-12-3153