@article{mbs:/content/journal/jgv/10.1099/0022-1317-68-12-3153, author = "Street, Alasdair J. and Griffin, Beverly E.", title = "Immunological Variation in the ‘Common Region’ of the T Antigens of Polyoma Virus", journal= "Journal of General Virology", year = "1987", volume = "68", number = "12", pages = "3153-3164", doi = "https://doi.org/10.1099/0022-1317-68-12-3153", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-12-3153", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "small T antigen", keywords = "protein kinase", keywords = "polyoma virus", abstract = "SUMMARY Characterization of a series of mouse monoclonal antibodies (designated αPy C21 to 26) against the region common to the large, middle and small T antigens of polyoma virus has revealed immunological diversities among the N termini of these antigens. Four of the antibodies (αPy C21 to 24) appeared to recognize all the T antigens present in lytically infected cells, but two of them (αPy C25, 26) failed to immunoprecipitate small T antigen either from 35S- or 32P-labelled cells and recognized only a subset of middle and large T antigens. None of the antibodies recognized the protein kinase activity normally associated with middle T antigen or the 60K mol. wt. antigen-related protein observed in polyoma virus lytically infected or transformed cells. The possible immunodominance of the N termini of the early gene products (as well as VP1) in the natural host of polyoma virus and the observed antigenic heterogeneity are considered.", }