1887

Abstract

Summary

Six caprine arthritis-encephalitis virus (CAEV)-free goats kept in strict isolation were inoculated intravenously with a cloned CAEV isolate (virus 020). At 78 weeks post-infection a virus (virus 095) isolated from one of the goats was shown to have the characteristics of CAEV, but was antigenically distinct from virus 020 and two other CAEV isolates by serum neutralization tests. Serum from the goat that had the variant virus neutralized the inoculum virus and the variant virus but serum from other inoculated goats neutralized only the inoculum virus. The variant virus and the inoculum virus were shown to co-exist in the infected goat, but the presence of the antigenic variant did not appear to be associated with an increase in severity of lesions compared with other inoculated goats.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-12-3145
1987-12-01
2022-01-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/12/JV0680123145.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-12-3145&mimeType=html&fmt=ahah

References

  1. Clements L. E., D’Antonio N., Narayan O. 1982; Genomic changes associated with antigenic variation of visna virus. II. Common nucleotide sequence changes detected in variants from independent isolations. Journal of Molecular Biology 158:415–434
    [Google Scholar]
  2. Coackley W., Smith V. W., Houwers D. J. 1984; Preparation and evaluation of antigens used in serological tests for caprine syncytial retrovirus antibody in sheep and goat sera. Veterinary Microbiology 9:581–586
    [Google Scholar]
  3. Crawford T. B., Cheevers W. P., Klevjer-Andersen P., Mcguire T. C. 1978; Equine infectious anaemia: virion characteristics, virus-cell interactions and host responses. In Persistent Viruses, ICN-UCLA Symposia on Molecular and Cellular Biology 11 pp 727–749 Stevens J. G., Todaro G. J., Fox C. F. Edited by New York & London: Academic Press;
    [Google Scholar]
  4. Crawford T. B., Adams D. S., Cheevers W. P., Cork L. C. 1980; Chronic arthritis in goats caused by a retrovirus. Science 207:997–999
    [Google Scholar]
  5. Dahlberg J. E., Gaskin J. M., Perk K. 1981; Morphological and immunological comparison of caprine arthritis encephalitis and ovine progressive pneumonia viruses. Journal of Virology 39:914–919
    [Google Scholar]
  6. Ellis T. M. 1986 Studies of caprine arthritis-encephalitis viruses, associated diseases and their control in Western Australia Ph.D.thesis Murdoch University:
    [Google Scholar]
  7. Ellis T. M., Robinson W., Wilcox G. 1983; Characterisation, experimental infection and serological response to caprine retrovirus. Australian Veterinary Journal 60:321–326
    [Google Scholar]
  8. Ellis T. M., Wilcox G. E., Robinson W. F. 1985; Characteristics of cell fusion induced by a caprine retrovirus. Archives of Virology 86:263–273
    [Google Scholar]
  9. Ellis T. M., Robinson W. F., Wilcox G. E. 1987; Comparison of caprine arthritis-encephalitis viruses isolated from goats with arthritis-synovitis and goats with chronic interstitial pneumonia. Australian Veterinary Journal in press
    [Google Scholar]
  10. Georgsson G., Nathanson N., Petursson G, Palsson P. A. 1980; The immunopathogenesis of visna. In Animal Models of Neurological Disease pp 378–389 Rose R. C., Behan P. O. Edited by London: Pitman;
    [Google Scholar]
  11. Gudnadottir M. 1974; Visna-maedi in sheep. Progress in Medical Virology 18:336–349
    [Google Scholar]
  12. Hyslop N. ST. G., Fagg R. H. 1965; Isolation of variants during passage of a strain of foot and mouth disease virus in partly immunised cattle. Journal of Hygiene 63:357–368
    [Google Scholar]
  13. Kono Y., Kobayashi K., Fukanaga Y. 1973; Antigenic drift of equine infectious anaemia virus in chronically infected horses. Archiv für die gesamte Virusforschung 41:1–10
    [Google Scholar]
  14. Laver W. G., Webster R. G. 1968; Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutinating proteins. Virology 34:193–202
    [Google Scholar]
  15. Lutley R, Pélsson P. A., Pálsson P. A., Georgsson G., Klein J., Nathanson N. 1983; Antigenic drift in visna: virus variation during long-term infection of Icelandic sheep. Journal of General Virology 64:1433–1440
    [Google Scholar]
  16. Narayan O., Griffin D. E., Chase J. 1977a; Antigenic shift of visna virus in persistently infected sheep. Science 197:376–378
    [Google Scholar]
  17. Narayan O., Griffin D. E., Silverstein A. M. 1977b; Slow virus infection: replication and mechanisms of persistence of visna virus in sheep. Journal of Infectious Diseases 135:800–806
    [Google Scholar]
  18. Narayan O., Griffin D. E., Clements J. E. 1978; Virus mutation during ‘slow infection’: temporal development and characterization of mutants of visna virus recovered from sheep. Journal of General Virology 41:343–352
    [Google Scholar]
  19. Narayan O., Clements J. E., Strandberg J. D., Cork L. C., Griffin D. E. 1980; Biological characterization of the virus causing leukoencephalitis and arthritis in goats. Journal of General Virology 50:69–70
    [Google Scholar]
  20. Narayan O., Clements J. E., Griffin D. E., Wolinsky J. S. 1981; Neutralising antibody spectrum determines the antigenic profiles of emerging mutants of visna virus. Infection and Immunity 32:1045–1050
    [Google Scholar]
  21. Narayan O., Cheffer D., Griffin D. E., Clements J. E., Hess J. 1984; Lack of neutralising antibody to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunisation with inactivated Mycobacterium tuberculosis . Journal of Virology 49:349–355
    [Google Scholar]
  22. Nathanson N., Georgsson G., Pálsson P. A., Najjar J. A., Lutley R., PéTursson G. 1985; Experimental visna in Icelandic sheep: the prototype lentiviral infection. Reviews of Infectious Disease 7:75–82
    [Google Scholar]
  23. Pétursson G., Nathanson N., Georgsson G., Panitch H., Pálsson P. A. 1976; Pathogenesis of visna. I. Sequential virologic, serologic and pathologic studies. Laboratory Investigation 35:402–412
    [Google Scholar]
  24. Porter D. D. 1975; Persistence of viral infection in the presence of immunity. In Viral Immunology and Immunopathology pp 189–200 Notkins A. L. Edited by New York & London: Academic Press;
    [Google Scholar]
  25. Reed L. J., Muench H. 1938; A simple method for estimating fifty percent endpoints. American Journal of Hygiene 27:493–497
    [Google Scholar]
  26. Scott J. V., Stowring L., Haase A. T., Narayan O., Vigne R. 1979; Antigenic variation in visna virus. Cell 18:321–327
    [Google Scholar]
  27. Sihvonen L. 1981; Early immune responses in experimental maedi. Research in Veterinary Science 30:217–222
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-12-3145
Loading
/content/journal/jgv/10.1099/0022-1317-68-12-3145
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error