1887

Abstract

SUMMARY

Enhancement of yellow fever virus neurovirulence for mice by specific antibody was studied with the French neurotropic vaccine strain. Experimental conditions for enhancement required mice between 14 and 40 days old and intraperitoneal administration of a selected monoclonal antibody 24 h before or up to 72 h after intracerebral virus challenge. Virus infectivity titrations were similar in brains of antibody-treated and untreated mice. Virus recovered from brains of mice with enhanced viral infections was neither qualitatively nor quantitatively different from standard virus. Humoral immune responses in enhanced infections were normal, macrophages did not become infected and viraemia was not significant. Both hydrocortisone treatment and complement depletion with cobra venom resulted in prolongation of mouse survival times but virulence enhancement persisted. Antithymocyte serum had no effect on enhancement although it reduced the humoral immune response. It is proposed that virulence enhancement is due to the combined effects of virus-specific antibody on infected cells, complement-mediated cytolysis and resultant host anti-cellular activity. There is no analogy between mechanisms effecting increased arbovirus growth in the presence of specific antibody and increased yellow fever virus neurovirulence after parenteral administration of antibody.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-68-12-3105
1987-12-01
2022-01-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/68/12/JV0680123105.html?itemId=/content/journal/jgv/10.1099/0022-1317-68-12-3105&mimeType=html&fmt=ahah

References

  1. Barrett A. D. T., Gould E. A. 1986; Antibody-mediated early death in vivoafter infection with yellow fever virus. Journal of General Virology 67:2539–2542
    [Google Scholar]
  2. Blancou J., Andral B., Andral L. 1980; A model in mice for the study of the early death phenomenon after vaccination and challenge with rabies virus. Journal of General Virology 50:433–435
    [Google Scholar]
  3. Bradish C. J., Fitzgeorge R., Titmuss D. 1980; The responses of normal and athymic mice to infections by togaviruses: strain differentiation in active and adoptive immunization. Journal of General Virology 46:255–265
    [Google Scholar]
  4. Buckley A., Gould E. A. 1985; Neutralization of yellow fever virus studied using monoclonal and polyclonal antibodies. Journal of General Virology 66:2523–2531
    [Google Scholar]
  5. Cammack N., Gould E. A. 1986; Topographical analysis of epitope relationships on the envelope glycoprotein of yellow fever 17D vaccine and the wild type Asibi parent virus. Virology 150:333–341
    [Google Scholar]
  6. Cardosa M. J., Porterfield J. S., Gordon S. 1983; Complement receptor mediates enhanced flavivirus replication in macrophages. Journal of Experimental Medicine 158:258–263
    [Google Scholar]
  7. Claman H. N. 1975; How corticosteroids work. Journal of Allergy and Clinical Immunology 55:145–151
    [Google Scholar]
  8. Doenhoff M. J., Leuchars E. 1977; Effects of radiation, anti-thymocyte serum and corticosteroids on PHA and LPS responsive cells of the mouse. International Archives of Allergy and Applied Immunology 53:505–515
    [Google Scholar]
  9. Fitzgeorge R., Bradish C. J. 1980; The in vivodifferentiation of strains of yellow fever virus in mice. Journal of General Virology 46:1–13
    [Google Scholar]
  10. Gould E. A., Buckley A., Cammack N. 1985a; Use of the biotin-streptavidin interaction to improve flavivirus detection by immunofluorescence and ELISA tests. Journal of Virological Methods 11:41–48
    [Google Scholar]
  11. Gould E. A., Buckley A., Cammack N., Barrett A. D. T., Clegg J. C. S., Ishak R., Varma M. G. R. 1985b; Examination of the immunological relationships between flaviviruses using yellow fever virus monoclonal antibodies. Journal of General Virology 66:1369–1382
    [Google Scholar]
  12. Gould E. A., Buckley A., Barrett A. D. T., Cammack N. 1986; Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice. Journal of General Virology 67:591–595
    [Google Scholar]
  13. Halstead S. B., Shotwell H., Casals J. 1973; Studies of the pathogenesis of dengue infection in monkeys. II.Clinical laboratory responses to heterologous infection. Journal of Infectious Diseases 128:15–22
    [Google Scholar]
  14. Hawkes R. A. 1964; Enhancement of infectivity of arboviruses by specific antisera produced in domestic fowls. Australian Journal of Experimental Biology and Medical Science 42:465–482
    [Google Scholar]
  15. Levey R. H. 1966; Some experiments on the action of antilymphoid antisera. Annals of the New York Academy of Sciences 129:164–177
    [Google Scholar]
  16. Oldstone M. B. A., Fujinami R. S., Lampert P. W. 1980; Membrane and cytoplasmic changes in virus-infected cells induced by interactions of antiviral antibody with surface viral antigen. Progress in Medical Virology 26:45–93
    [Google Scholar]
  17. Peiris J. S. M., Gordon S., Unkeless J. C., Porterfield J. S. 1981; Monoclonal anti-Fc receptor IgG BLOCKS antibody enhancement of viral replication in macrophages. Nature; London: 289189–191
    [Google Scholar]
  18. Prabhakar B. S., Nathanson N. 1981; Acute rabies death mediated by antibody. Nature; London: 290590–591
    [Google Scholar]
  19. Scott D. W., Gershon R. K. 1970; Determination of total and mercaptoethanol resistant antibody in the same serum sample. Clinical and Experimental Immunology 6:313–316
    [Google Scholar]
  20. Scott R. McN., Eckels K. H., Bancroft W. H., Summers P. L., Mccown J. M., Anderson J. H., Russell P. K. 1983; Dengue 2 vaccine: dose response in volunteers in relation to yellow fever immune status. Journal of Infectious Diseases 148:1055–1060
    [Google Scholar]
  21. Sikes R. K., Cleary W. F., Koprowski H., Kaplan M. M. 1971; Effective protection of monkeys against death from street rabies by post-exposure administration of tissue culture rabies vaccine. Bulletin of the World Health Organization 45:1–11
    [Google Scholar]
  22. Weiss R. W., Scott F. W. 1981; Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. Comparative Immunology, Microbiology and Infectious Diseases 4:175–189
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-12-3105
Loading
/content/journal/jgv/10.1099/0022-1317-68-12-3105
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error