The nucleotide sequences of the adjacent genes coding for the F protein and 22K protein of the RSS-2 strain of human respiratory syncytial (RS) virus were determined from cDNA clones of genomic RNA. Comparison of these sequences and the inferred amino acid sequences of the F and 22K proteins with the corresponding published sequences of another subgroup A virus, the A2 strain of RS virus, reveals extensive overall homology (>95%) at both the nucleotide and amino acid levels, even though these two viruses were isolated 15 years apart in different continents. The intergenic region and the hydrophobic amino-terminal signal sequence of the F proteins of the two viruses, however, are much less conserved.


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