1887

Abstract

SUMMARY

The coding sequences of the hepatitis B virus surface antigen were inserted into a baculovirus transfer vector produced from nuclear polyhedrosis virus (AcNPV) so that the foreign gene was under the control of the AcNPV polyhedrin promoter. cells infected with the derived recombinant baculovirus produced and secreted 22 nm particles containing the hepatitis B surface antigen. The particles had morphological and antigenic properties identical to those of 22 nm particles isolated from the plasma of chronic active hepatitis patients.

Keyword(s): AcNPV , baculovirus and HBsAg
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/content/journal/jgv/10.1099/0022-1317-68-10-2607
1987-10-01
2022-01-18
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