1887

Abstract

Summary

Reduced temperature has been shown to block the cell surface expression of Sendai virus haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins at different steps of their intracellular transport. At 20 °C, HN was confined to the rough endoplasmic reticulum or cis Golgi compartment, while F acquired complete resistance to digestion by endo-β--acetylglucosaminidase-H and therefore was blocked at a more distal location in the pathway of cell surface expression. The significance of these results for different pathways of transport to the cell surface is discussed.

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/content/journal/jgv/10.1099/0022-1317-67-9-2029
1986-09-01
2022-01-21
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