1887

Abstract

Summary

A significant decrease in mortality was observed when 25 µg of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukaemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 µg dose of tuftsin given 5 days before and twice-weekly for 3 weeks had no effect on leukaemia induced by FLV infection. These findings showed that time and dosage were critical to the protective effect of tuftsin against virus-induced leukaemia.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-67-9-2001
1986-09-01
2021-10-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/67/9/JV0670092001.html?itemId=/content/journal/jgv/10.1099/0022-1317-67-9-2001&mimeType=html&fmt=ahah

References

  1. Catane R., Schlanger S., Weiss L., Fuks Z. 1983; Toxicology and antitumour activity of tuftsin. Annals of the New York Academy of Sciences 419:251–260
    [Google Scholar]
  2. Catane R., Sulkes A., Uziely B., Gez E., Isacson R., Treves A. J., Fridkin M. 1986; Initial clinical studies with tuftsin. Drugs under Experimental and Clinical Research (in press)
    [Google Scholar]
  3. Chaudhuri M. K., Najjar V. A. 1979; Solid phase tuftsin (Thr-Lys-Pro-Arg) synthesis: deprotection and resin cleavage with trifluoromethane sulfonic acid. Analytical Biochemistry 95:305–310
    [Google Scholar]
  4. Ergaz Z., Warner-Efrati E., Gabizon A., Treves A. J., Fridkin M., Catane R. 1985; Enhancement of immunogenic and tumoricidal effects of tuftsin by entrapment in liposomes. Abstracts, 7th European Immunology Meeting (Jerusalem, Israel; September 8–13, 1985)
    [Google Scholar]
  5. Friedman H. 1974; Effects of the Friend leukemia virus on cells of the immune system. Israel Journal of Medical Sciences 10:1052–1074
    [Google Scholar]
  6. Garaci E., Miglorati G., Jezzi T. 1981; Impairment of in vitro generation of cytotoxic or T suppressor lymphocytes by Friend leukemia virus infection in mice. European Journal of Cancer 17:129–142
    [Google Scholar]
  7. Goldin A., Venditti J. M., Macdonald J. S., Muggia F. M., Henney J. E., Henney J. E., Devita V. T. JR 1981; Current results of the screening program at the Division of Cancer Treatment, National Cancer Institute. European Journal of Cancer 17:129–142
    [Google Scholar]
  8. Knyszynski A., Gottlieb P., Fridkin M. 1983; Inhibition by tuftsin of Rauscher virus leukemia development in mice. Journal of the National Cancer Institute 71:87–90
    [Google Scholar]
  9. Levy S. B., Rubenstein C. B. Friend C. H. 1976; The spleen in Friend leukemia. I. Prolonged survival of leukemic mice after auto-implantation of spleen tissue. Journal of the National Cancer Institute 56:1183–1188
    [Google Scholar]
  10. Maranaska K., Nobuko S., Sakurai A. 1984; Antitumour activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice. International Journal of Cancer 34:263–267
    [Google Scholar]
  11. Moody D. J., Specter S., Bendinelli M., Friedman H. 1984; Suppression of natural killer cell activity by Friend murine leukemia virus. Journal of the National Cancer Institute 72:1349–1356
    [Google Scholar]
  12. Najiar V. A. 1983; A natural activator of phagocytosis cells: an overview. Annals of the New York Academy of Sciences 419:1–12
    [Google Scholar]
  13. Najjar V. A., Bump N. J. 1984; Tuftsin (Thr–Lys-Pro-Arg). A stimulator of all known functions of macrophage. In Immune Modulation Agents and Their Mechanism pp. 229–242 Edited by Fenichel R. L., Chirigos M. A. New York: Marcel Dekker;
    [Google Scholar]
  14. Najjar V. A., Nishioka K. 1970; Tuftsin -a physiological phagocytosis stimulating peptide. Nature, London 228:672–673
    [Google Scholar]
  15. Nishioka K., Satoh P., Constantopoulos A., Najjar V. A. 1973; The chemical synthesis of phagocytosis stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties. Biochimica et biophysica acta 310:230–239
    [Google Scholar]
  16. Nishioka K., Babcock G. F., Phillips J. H., Noyes R. D. 1981; Antitumor effect of tuftsin. Molecular and Cellular Biochemistry 41:13–18
    [Google Scholar]
  17. Nishioka K., Babcock G. F., Phillips J. H., Banks R. A., Amoscato A. A. 1983; In vivo and in vitro antitumor activities of tuftsin. Annals of the New York Academy of Sciences 419:261–267
    [Google Scholar]
  18. Phillips J. H., Babcock G. F., Nishioka K. 1981; Tuftsin: a naturally occurring immunopotentiating factor. I. In vitro enhancement of murine natural cell–mediated cytotoxicity. Journal of Immunology 126:915–921
    [Google Scholar]
  19. Schultz R. M., Papamatheakis D., Luetzeler J., Chirigos M. A. 1977; Association of macrophage activation with antitumor activity by synthetic and biological agents. Cancer Research 37:3338–3345
    [Google Scholar]
  20. Suyama K., Goldstein J., Gree S. 1985; Effects of murine tumor necrosis factor on Friend erythroleukemic cells. Experimental and Cellular Biology 53:85–92
    [Google Scholar]
  21. Wleklik M., Luczak M., Najjar V. A. 1985; Tuftsin-induced antitumor activity. Abstracts, Symposium of The Polish Society for Virology (Lodz, Poland; September 9–10, 1985)
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-67-9-2001
Loading
/content/journal/jgv/10.1099/0022-1317-67-9-2001
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error