1887

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Volume 67, Issue 8

Genetic Reassortment between Two Human Rotaviruses Having Different Serotype and Subgroup Specificities Free

Abstract

Summary

Two reassortant viruses were selected from a mixed infection of MA104 cells with human rotavirus strains Wa (serotype 1-subgroup II) and HN126 (serotype 2-subgroup I). Antigenic characterization and genotype analysis by polyacrylamide gel electrophoresis revealed that they were reassortants with novel antigenic compositions, i.e. serotype 1-subgroup I (C116) and serotype 2-subgroup II (C15). Furthermore one of them, C15, was considered to have a mosaic antigenicity defined by two serotype-specific antigens, namely the serotype 1-specific VP3 antigen and the serotype 2-specific VP7 antigen. Although this reassortant was shown to be a serotype 2 virus on the basis of its preferential reactivity in neutralization reactions with serotype 2 antiserum, unexpectedly the antiserum prepared against C15 equally neutralized both serotype 1 and serotype 2 strains.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antigens , human , reassortment , rotavirus and subgroup and serotype
© Journal of General Virology 1986
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1986-08-01
2024-04-25
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Genetic Reassortment between Two Human Rotaviruses Having Different Serotype and Subgroup Specificities
J. Gen. Virol. 67, 1551 (1986); https://doi.org/10.1099/0022-1317-67-8-1551
/content/journal/jgv/10.1099/0022-1317-67-8-1551
/content/journal/jgv/10.1099/0022-1317-67-8-1551
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