@article{mbs:/content/journal/jgv/10.1099/0022-1317-67-2-281, author = "Rydbeck, Robert and Löve, Arthur and Örvell, Claes and Norrby, Erling", title = "Antigenic Variation of Envelope and Internal Proteins of Mumps Virus Strains Detected with Monoclonal Antibodies", journal= "Journal of General Virology", year = "1986", volume = "67", number = "2", pages = "281-287", doi = "https://doi.org/10.1099/0022-1317-67-2-281", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-67-2-281", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "antigenic subtypes", keywords = "monoclonal antibodies", keywords = "mumps virus", abstract = "Summary Antigenic characteristics of nine mumps virus strains were determined by immunofluorescence and radioimmunoprecipitation assay (RIPA) using a collection of 44 monoclonal antibodies. These antibodies were directed against five different structural components of mumps virus, the haemagglutinin-neuraminidase (HN), fusion (F), matrix (M), phospho- (P) and nucleocapsid (NP) proteins. The nine mumps virus strains could be divided into two groups according to their antigenic characteristics. One group included two strains isolated more than a decade ago and the Jeryl Lynn vaccine strain. These three strains reacted with a wider range of monoclonal antibodies than the second group of six recently isolated strains of different geographical origin. In the F, M and P proteins variations were only found in single antigenic determinants. In the HN and NP components, RIPA revealed variations in three and seven determinants respectively. The Jeryl Lynn vaccine strain showed a unique lack of reaction with one anti-HN antibody clone in the RIPA.", }