RT Journal Article SR Electronic(1) A1 Seid, J. M. A1 Liberto, M. A1 Bonina, L. A1 Leung, K.-N. A1 Nash, A. A.YR 1986 T1 T Cell-Macrophage Interactions in the Immune Response to Herpes Simplex Virus: the Significance of Interferon-γ JF Journal of General Virology, VO 67 IS 12 SP 2799 OP 2802 DO https://doi.org/10.1099/0022-1317-67-12-2799 PB Microbiology Society, SN 1465-2099, AB Summary The antiviral properties of a herpex simplex virus type 1-specific ‘helper’ T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-γ upon stimulation with the virus in vitro. Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages in vitro and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-γ in the clone supernatant. The implications of these results for protection against this virus in vivo are discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-67-12-2799