1887

Abstract

Summary

The antiviral properties of a herpex simplex virus type 1-specific ‘helper’ T cell clone were investigated. The clone was found to be deficient in interleukin 2 production, although it produced interleukin 3 and interferon-γ upon stimulation with the virus . Supernatants containing these lymphokines were observed to increase the virocidal activity of macrophages and furthermore induced these cells to mediate cytotoxic activity against virus-infected target cells. Macrophage activation was linked to the presence of interferon-γ in the clone supernatant. The implications of these results for protection against this virus are discussed.

Keyword(s): HSV-1 , interferon (MuIFN-γ) and T cells
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/content/journal/jgv/10.1099/0022-1317-67-12-2799
1986-12-01
2019-11-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-67-12-2799
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