RT Journal Article SR Electronic(1) A1 Schneider, Josef A1 Kaaden, Oskar A1 Copeland, Terry D. A1 Oroszlan, Steven A1 Hunsmann, GerhardYR 1986 T1 Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency Virus JF Journal of General Virology, VO 67 IS 11 SP 2533 OP 2538 DO https://doi.org/10.1099/0022-1317-67-11-2533 PB Microbiology Society, SN 1465-2099, AB Summary Two glycopolypeptides with molecular weights 160000 and 120000 (gp120) are regularly recognized by human immunodeficiency virus (HIV)-specific antisera in lysates of cells persistently infected with HIV. In the present study, gp120 was characterized as the major envelope glycopolypeptide of HIV. Gp120 was identified as the external viral glycoprotein by radiosequencing and by its presence in purified virus. However gp120 was predominantly shed as a soluble protein into the culture fluid. Furthermore gp120 was precipitated by sera from horses infected with equine infectious anaemia virus (EIAV), but not by sera from uninfected animals. This may indicate conserved epitopes common to the envelopes of HIV and EIAV., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-67-11-2533