1887

Abstract

Summary

Assembly of the coat protein subunits of tobacco mosaic virus (TMV) into 20S aggregates (‘disks’) and long helices was monitored by light scattering and electron microscopy. The anti-microtubule agent methyl benzimidazol-2-yl carbamate, which inhibits TMV multiplication , did not affect assembly of coat protein . In contrast, the anti-microtubule agents colchicine and vinblastine inhibited disk formation, but stimulated rod elongation from coat protein subunits . Both agents also disrupted preformed disks. Vinblastine inhibited virus multiplication in leaf tissue, but colchicine did not.

Keyword(s): coat protein , colchicine , MBC , TMV , tubulin and vinblastine
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/content/journal/jgv/10.1099/0022-1317-67-11-2489
1986-11-01
2021-10-25
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