1887

Abstract

SUMMARY

Mice previously latently infected with the F strain of herpes simplex virus type 1 (HSV-1) can be successfully colonized with a second virus strain if HSV-2 is introduced at the same peripheral site as HSV-1. On the other hand, HSV-1 strains seemed able mutually to exclude establishment of latency with each other. Mice (3 months or 3 years after nasal infection) latently infected with HSV-1 were thus superinfected with HSV-2. The mice were sacrified 2 days post-infection when HSV-2 replication in the ganglia was found to have commenced. Ganglia were homogenized immediately and virus was plaqued on permissive cells. HSV-1 plaques were regularly obtained among HSV-2 plaques as assessed by staining with an enzyme-linked immunosorbent using a type-specific monoclonal antibody recognizing glycoprotein C of HSV-1. DNA from this virus had identical restriction endonuclease patterns (RI, HI and dIII) to the F strain used to infect the animals latently. HSV-1 was not retrieved from ganglia of controls superinfected with a neuroadapted vaccinia virus or were mock-superinfected. The results suggest that it is possible to superinfect a latently infected ganglionic neuronal cell with a heterotypic HSV strain and that the subsequently introduced HSV-2 can act in trans to induce reactivation of latent HSV-1.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-8-1763
1985-08-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/8/JV0660081763.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-8-1763&mimeType=html&fmt=ahah

References

  1. Brown S. M., Subak–Sharpe J. H., Warren K. G., Wroblewska Z., Koprowski H. 1979; Detection by complementation of defective or uninducible herpes simplex type 1 virus genomes latent in human ganglia. Proceedings of the National Academy of Sciences, U. S. A 76:2364–2368
    [Google Scholar]
  2. Buchman T. G., Roizman B., Adams G., Stover B. H. 1978; Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. Journal of Infectious Diseases 138:488–498
    [Google Scholar]
  3. Centifanto-Fitzgerald Y. M., Varnell E. D., Kaufman H. E. 1982; Initial herpes simplex virus type 1 infection prevents ganglionic superinfection by other strains. Infection and Immunity 35:1125–1132
    [Google Scholar]
  4. Green M., Miller H., Hendler S. 1971; Isolation Of A Polyoma-Nucleoprotein complex from infected mouse cell cultures. Proceedings of the National Academy of Sciences, U. S. A 68:1032–1036
    [Google Scholar]
  5. Gunalp A. 1965; Growth and cytopathic effect of rubella virus in a line of green monkey kidney cells. Proceedings of the Society for Experimental Biology and Medicine 118:85–90
    [Google Scholar]
  6. Harbour D. A., Hill T. J., Blyth W. A. 1981; Acute and recurrent herpes simplex in several strains of mice. Journal of General Virology 55:31–40
    [Google Scholar]
  7. Jeansson S. 1972; Differentiation between herpes simplex virus type 1 and type 2 strains by immunoelectroos–mophoresis. Applied Microbiology 24:96–100
    [Google Scholar]
  8. Knotts F. B., Cook M. L., Stevens J. G. 1973; Latent herpes simplex virus in the central nervous system of rabbits and mice. Journal of Experimental Medicine 138:740–744
    [Google Scholar]
  9. Kristensson K., Vahlne A., Persson L. A., Lycke E. 1978; Neuralspreadof herpes simplex virus types 1 and 2 after corneal or subcutaneous (footpad) inoculation. Journal of the Neurological Sciences 35:331–340
    [Google Scholar]
  10. Kristensson K., Svennerholm B., Persson L., Vahlne A., Lycke E. 1979; Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system. Journal of the Neurological Sciences 43:253–264
    [Google Scholar]
  11. Kristensson K., Svennerholm B., Vahlne A., Nilheden E., Persson L., Lycke E. 1982; Virus-induced demyelination in herpes simplex virus-infected mice. Journal of the Neurological Sciences 53:205–216
    [Google Scholar]
  12. Lewis M. E., Leung W.-C., Jeffrey V. M., Warren K. G. 1983; Detection of multiple strains of latent HSV-1 within individual human hosts. Abstracts, International Herpesvirus Workshop (Oxford, U. K.) p 171
    [Google Scholar]
  13. Lewis M. E., Brown S. M., Warren K. G., Subak-Sharpe J. H. 1984; Recovery of herpes simplex virus genetic information from human trigeminal ganglion cells following superinfection with herpes simplex virus type 2 temperature-sensitive mutants. Journal of General Virology 65:215–219
    [Google Scholar]
  14. Lonsdale D. M., Brown S. M., Subak-Sharpe J. H., Warren K. G., Koprowski H. 1979; The polypeptide and the DNA restriction enzyme profiles of spontaneous isolates of herpes simplex virus type 1 from explants of human trigeminal, superior cervical and vagus ganglia. Journal of General Virology 43:151–171
    [Google Scholar]
  15. Mckendall R. R. 1977; Efficacy of herpes simplex virus type 2 in mice. Infection and Immunity 16:717–719
    [Google Scholar]
  16. Meigner B., Norrild B., Roizman B. 1983; Colonization of murine ganglia by a superinfecting strain of herpes simplex virus. Infection and Immunity 41:702–708
    [Google Scholar]
  17. Nilheden E., Jeansson S., Vahlne A. 1983; Typing of herpes simplex virus by an enzyme-linked immunosorbent assay with monoclonal antibodies. Journal of Clinical Microbiology 17:677–680
    [Google Scholar]
  18. Nilheden E., Jeansson S., Vahlne A. 1985a; Amplification of herpes simplex virus resistance in mouse neuroblastoma (Cl300) cells. Archives of Virology 83:269–283
    [Google Scholar]
  19. Nilheden E., Jeansson S., Vahlne A. 1985b; Herpes simplex virus latency in a hyperresistant clone of mouse neuroblastoma (C1300) cells. Archives of Virology 83:319–325
    [Google Scholar]
  20. Pignani P. F., Cassai E., Meneguzzi G., Chenciner N., Milanesi G. 1979; Herpes simplex virus DNA isolation from infected cells with a novel procedure. Virology 93:260–264
    [Google Scholar]
  21. Plummer G. 1973; Isolation of herpes viruses from the trigeminal ganglia of man, monkeys and cats. Journal of Infectious Diseases 128:345–348
    [Google Scholar]
  22. Plummer G., Hollingsworth D. C., Phuangab A., Bowling C. P. 1970; Chronic infections by herpes simplex viruses and by the horse and cat herpes viruses. Infection and Immunity 1:351–355
    [Google Scholar]
  23. Price R. W., Walls M. A., Wohlenberg C., Notkins A. L. 1975; Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. Science 188:938–940
    [Google Scholar]
  24. Stevens J. G., Cook M. L. 1971; Latent herpes simplex virus in spinal ganglia of mice. Science 173:843–845
    [Google Scholar]
  25. Stevens J. G., Nesburn A. B., Cook M. L. 1972; Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. Nature New Biology 235:216–217
    [Google Scholar]
  26. Vahlne A., Blomberg J., Olofsson S., Lycke E. 1975; Subtyping of herpes simplex virus. Acta pathologica et microbiologica scandinavica Section B 83:506–512
    [Google Scholar]
  27. Vahlne A., Svennerholm B., Lycke E. 1979; Evidence for herpes simplex virus type-selective receptors on cellular plasma membranes. Journal of General Virology 44:217–225
    [Google Scholar]
  28. Vahlne A., Nilheden E., Svennerholm B. 1981; Multiplicity activation of herpes simplex virus in mouse neuroblastoma (Cl300) cells. Archives of Virology 70:345–356
    [Google Scholar]
  29. Wildy P., Field H. J., Nash A. A. 1982; Classical herpes latency revisited. In Virus Persistence, 33rd Symposium of the Society for General Microbiology pp 133–167 Edited by Mahy B. W. J., Minson A. C., Darby G. K. Cambridge: Cambridge University Press;
    [Google Scholar]
  30. Wohlenberg C., Openshaw H., Notkins A. L. 1979; In vitro system for studying efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus. Antimicrobial Agents and Chemotherapy 15:625–627
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-8-1763
Loading
/content/journal/jgv/10.1099/0022-1317-66-8-1763
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error