Newborn rats were inoculated intraperitoneally with haemorrhagic fever with renal syndrome (HFRS)-related virus (B-1 strain), and virus isolation from their various organs was attempted between 1 and 25 weeks after inoculation. Virus could be isolated repeatedly from lung, brain, spleen and kidney and also from peripheral blood. When virus isolation was carried out on fractionated peripheral blood cells, virus was associated mainly with the macrophage fraction and to a lesser extent with granulocytes. Virus replicated well in peritoneal exudate cells of normal rats and it grew in the adherent mononuclear cells from normal human peripheral blood. These data suggest that macrophages, permissive for HFRS-related virus replication, might contribute to the spread of viral infection in vivo.
AllisonA. C.,
DaviesP.,
PageR. C.1973; Effects of endotoxin on macrophages and other lymphoreticular cells. Journal of Infectious Diseases (supplement 128) 212–219
BangF. B.,
WarwickA.1960; Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proceedings of the National Academy of Sciences, U,. S,. A 46:1065–1075
BraunR. W.,
TeuteH. K.,
KirchnerH.,
MunkK.1984; Replication of herpes simplex virus in human T lymphocytes: characterization of the viral target cell. Journal of Immunology 132:914–919
CasalsJ.,
HoogstraalH.,
JohnsonK. M.,
ShelokovA.,
WiebengaN. H.,
WorkT.1966; A Current appraisal of hemorrhagic fever in the U.S.S.R. American Journal of Tropical Medicine and Hygiene 15:751–764
CohenM. S.,
CasalsJ.,
HsiungD-G.,
KweiH.,
ChinC.,
GeH.,
HsiangC.,
LeeP. W.,
GibbsC. J.Jr,
GajdusekD. C.1981; Epidemic haemorrhagic fever in Hubei province, the People’s Republic of China: a clinical and serological study. Yale Journal of Biology and Medicine 54:41–55
DesmyterJ.,
LeducJ. W.,
JohnsonK. M.,
BrasseurF.,
DeckersC.,
van Ypersele StrihouC.1983; Laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to Hantaan-like virus in Belgium. Lancet ii:1445–1448
EdelmanR.,
WheelockE. F.1967; Specific role of each human leukocyte type in viral infections. I. Monocyte as host cell for vesicular stomatitis virus replicationin vitro. Journal of Virology 1:1139–1149
HalsteadS. B.,
O’RourkeE. J.,
AllisonA. C.1977; Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supportingin vitro infection. Journal of Experimental Medicine 146:218–229
HirschM. S.1984; Pathogenesis of viral infections. In Antiviral Agents and Viral Diseases of Man 2nd edn., pp 35–54 Edited by
GalassoG. J.,
MeriganT. C.,
BuchananR. A.
New York: Raven Press;
HottaH.,
HottaS.1982; Dengue virus multiplication in cultures of mouse peritoneal macrophages: effects of macrophage activators. Microbiology and Immunology 26:665–676
JosephB. S.,
LampertP. W.,
OldstoneM. B. A.1975; Replication and persistence of measles virus in defined subpopulations of human leukocytes. Journal of Virology 16:1638–1649
KawamataJ.1983; Studies on the Surveillance and Control Measures of Zoonoses Associated with Animal Experimentation with Special Reference to Hemorrhagic Fever. A report from the Ministry of Education, Cultural Affairs and Science (in Japanese)
KitamuraT.,
MoritaC.,
KomatsuT.,
SugiyamaK.,
ArikawaJ.,
ShigaS.,
TakedaH.,
AkaoY.,
ImaizimiK.,
OyaA.,
HashimotoN.,
UrasawaS.1983; Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Japanese Journal of Medical Science and Biology 36:17–25
KumagaiK.,
ItohK.,
HinumaS.,
TadaM.1979; Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation. Journal of Immunological Methods 29:17–25
LeeH. W.,
BaekL. J.,
JohnsonK. M.1982a; Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. Journal of Infectious Diseases 146:638–644
LeeP. W.,
AmyxH. L.,
GajdusekD. C.,
YanagiharaR. T.,
GoldgaberD.,
GibbsC. J.1982b; New hemorrhagic fever with renal syndrome-related virus in indigenous wild rodents in the United States. Lancet ii:1405
LevittN. H.,
MillerH. V.,
EdelmanR.1979; Interaction of alphaviruses with human peripheral leukocytes:in vitro replication of Venezuelan equine encephalitis virus in monocyte cultures. Infection and Immunity 24:642–646
NahmiasA. J.,
KibrickS.,
RosanR. C.1964; Viral leukocyte interrelationships. I. Multiplication of a DNA virus - herpes simplex - in human leukocyte cultures. Journal of Immunology 93:69–74
RinaldoC. R.Jr,
RichterB. S.,
BlackP. H.,
CalleryR.,
ChessL.,
HirschM. S.1978; Replication of herpes simplex virus and cytomegalovirus in human leukocytes. Journal of Immunology 120:130–136
SullivanJ. L.,
BarryD. W.,
LucasS. J.,
AlbrechtP.1975; Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. Journal of Experimental Medicine 142:773–784
TheofilopoulosA. N.,
BrandtW. E.,
RussellP. K.,
DixonF. T.1976; Replication of dengue-2 virus in cultured human lymphoblastoid cells and subpopulations of human peripheral leukocytes. Journal of Immunology 117:953–961
TurnerG. S.,
BallardR.1976; Interaction of mouse peritoneal macrophages with fixed rabies virusin vivo andin vitro. Journal of General Virology 30:223–231
WestmorelandD.1978; Herpes simplex virus type-1 and human lymphocytes: virus expression and the response to infection of adult and foetal cells. Journal of General Virology 40:559–575
WheelockE. F.,
EdelmanR.1969; Specific role of each human leukocyte type in viral infections. III. 17D yellow fever virus replication and interferon production in homogeneous leukocyte cultures treated with phytohemagglutinin. Journal of Immunology 103:429–436
WillemsF. T. C.,
MelnickJ. L.,
RawlsW. E.1969; Replication of poliovirus in phytohemagglutinin-stimulated human lymphocytes. Journal of Virology 3:451–457
YamanishiK.,
DantasF. J. R.,
TakahashiM.,
YamanouchiT.,
DomaeK.,
KawamataJ.,
KurataT.1983; Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. Biken Journal 26:155–160
YamanishiK.,
DantasJ. R.Jr,
TakahashiM.,
YamanouchiT.,
DomaeK.,
TakahashiY.,
TanishitaO.1984; Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. Journal of Virology 52:231–237