1887

Abstract

SUMMARY

Rinderpest virus (RV) grew readily in cultures of purified bovine peripheral blood lymphocytes and udder macrophages. The growth of three strains of RV was compared and there appeared to be a relationship between increasing virulence and increased ability to infect lymphocytes and macrophages. The proportion of infected cells as determined by the presence of virus antigens was a better indicator of affinity between a strain and cell type than production of new infectious virus. RV grew better in populations of predominantly T lymphocytes than in T-depleted cultures. Although RV could infect 100% of cells in macrophage monolayers, it did not appear to infect more than about 30% of cells in lymphocyte cultures. Virulent RV grew more readily in bovine than caprine or ovine lymphocytes, whereas virulent peste des petits ruminants virus (PPRV) grew better in lymphocytes from sheep and goats. There was no marked difference in the growth of either virus in lymphocytes from uninfected or recently convalescent animals.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-5-969
1985-05-01
2022-08-10
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/5/JV0660050969.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-5-969&mimeType=html&fmt=ahah

References

  1. Allison A. C. 1974; On the role of macrophages in immunity against viruses. Progress in Medical Virology 18:15–31
    [Google Scholar]
  2. Appel M. J. G. 1978; Reversion to virulence of attenuated canine distemper virus in vivo and in vitro . Journal of General Virology 41:385–393
    [Google Scholar]
  3. El Hag Ali B., Taylor W. P. 1984; Isolation of peste des petits ruminants virus from the Sudan. Research in Veterinary Science 36:1–4
    [Google Scholar]
  4. Huddlestone J. R., Lampert P. W., Oldstone M. B. A. 1980; Virus-lymphocyte interactions: infection of TG and Tm subsets by measles virus. Clinical Immunology and Immunopathology 15:502–509
    [Google Scholar]
  5. Joseph B. S., Lampert P. W., Oldstone M. B. A. 1975; Replication and persistence of measles virus in defined subpopulations of human leucocytes. Journal of Virology 16:1638–1649
    [Google Scholar]
  6. Liess B., Plowright W. 1963; The propagation and growth characteristics of rinderpest virus in HeLa cells. Archives of Virology 14:27–38
    [Google Scholar]
  7. Nawathe D. R., Lamorde A. G., Kumar S. 1983; Recrudescence of rinderpest in Nigeria. Veterinary Record 113:156
    [Google Scholar]
  8. Parish C. R., Kirov S. M., Bowern N., Blanden R. V. 1974; A one-step procedure for separating mouse thymus derived and bone marrow derived lymphocytes. Journal of Immunology 4:808–811
    [Google Scholar]
  9. Pearson T. W., Roelants G. E., Lundin L. B., Mayor-Withey K. S. 1979; The bovine lymphoid system: binding and stimulation of peripheral blood lymphocytes by lectins. Journal of Immunological Methods 26:271–282
    [Google Scholar]
  10. Pigoury L., Vacher B., Chabassol C., Pousset A. 1967; Note sur la culture du virus bovipestique lapinisé en cultures cellulaires de leucocytes de boeuf. Annales de l’Institut Pasteur 113:631–634
    [Google Scholar]
  11. Plowright W. 1963; Some properties of strains of rinderpest virus recently isolated in East Africa. Research in Veterinary Science 4:96–108
    [Google Scholar]
  12. Plowright W. 1964; The growth of virulent and attenuated strains of rinderpest virus in primary calf kidney cells. Archives of Virology 14:431–448
    [Google Scholar]
  13. Plowright W. 1968; Rinderpest virus. Monographs in Virology 3:25–110
    [Google Scholar]
  14. Plowright W., Ferris R. D. 1962; Studies with rinderpest virus in tissue culture. The use of an attenuated culture virus as a vaccine for cattle. Research in Veterinary Science 3:172–182
    [Google Scholar]
  15. Poste G. 1971; The growth and cytopathology of virulent and attenuated strains of canine distemper virus in dog and ferret macrophages. Journal of Comparative Pathology 81:49–54
    [Google Scholar]
  16. Rossiter P. B., Jessett D. M. 1982; Microtitre techniques for the assay of rinderpest virus and neutralising antibody. Research in Veterinary Science 32:253–256
    [Google Scholar]
  17. Rossiter P. B., Jessett D. M., Wafula J. S., Karstad L., Chema S., Taylor W. P., Rowe L., Nyangi J. C., Otaru M., Mumbala M., Scott G. R. 1983; Re-emergence of rinderpest as a threat in East Africa since 1979. Veterinary Record 113:459–461
    [Google Scholar]
  18. Rouse B. T., Wardley R. C., Babiuk L. A. 1976; Antibody-dependent cell-mediated cytotoxicity in cows. Comparison of effector cell activity against heterologous erythrocyte and herpesvirus infected bovine target cells. Infection and Immunity 13:1433–1441
    [Google Scholar]
  19. Sullivan J. L., Barry D. W., Lucas S. J., Albrecht P. 1975; Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. Journal of Experimental Medicine 142:778–784
    [Google Scholar]
  20. Taylor W. P., Plowright W. 1965; Studies on the pathogenesis of rinderpest in experimental cattle. III. Proliferation of an attenuated strain in various tissues following subcutaneous inoculation. Journal of Hygiene 63:263–275
    [Google Scholar]
  21. Tokuda G., Fukusho K., Morimoto T., Watanabe M. 1962; Studies on rinderpest virus in bovine leucocyte culture. I. Cultivation of leucocytes and appearance of inclusions in infected cells. National Institute of Animal Health Quarterly 2:189–200
    [Google Scholar]
  22. Usinger W. R., Smith W. G., Splitter G. A. 1981; Bovine T cells do not require auxiliary cells for response to selected mitogens. Veterinary Immunology and Immunopathology 2:381–391
    [Google Scholar]
  23. Wardley R. C., Rouse B. T., Babiuk L. A. 1976; The mammary gland of the ox: a convenient source for the repeat collection of neutrophils and macrophages. Journal of the Reticuloendothelial Society 19:29–36
    [Google Scholar]
  24. Zweiman B., Lisak R. P., Waters D., Koprowski H. 1979; Effects of purified measles virus components in proliferating human lymphocytes. Cellular Immunology 47:241–247
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-5-969
Loading
/content/journal/jgv/10.1099/0022-1317-66-5-969
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error