1887

Abstract

Summary

Cytotoxic T lymphocytes (CTL) against alphavirus-infected L929 cells were generated in mice by two immunizations of one virus or by immunization followed by stimulation of splenocytes with infected peritoneal exudate cells or splenocytes. These CTL caused specific H-2-restricted cytolysis equally well with homologous, heterologous or Sindbis virus 20 mutant-infected cells. Thus, specific CTL appear to be cross-reactive components in normal immunity to alphaviruses and the E1 glycoprotein is implicated as the target antigen.

Keyword(s): CTL , E1 glycoprotein and Sindbis virus
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/content/journal/jgv/10.1099/0022-1317-66-5-1167
1985-05-01
2019-11-23
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-5-1167
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