RT Journal Article SR Electronic(1) A1 Tóth, Miklós A1 Endrész, Valéria A1 Tóth, Sándor A1 Béládi, IlonaYR 1985 T1 Human Interferons Alpha and Beta Have More Potent Priming Activities than Interferon Gamma JF Journal of General Virology, VO 66 IS 4 SP 893 OP 896 DO https://doi.org/10.1099/0022-1317-66-4-893 PB Microbiology Society, SN 1465-2099, AB SUMMARY The priming activities of human IFN-α, IFN-β and IFN-γ were compared on the same antiviral basis using human buffy coat leukocytes stimulated with Sendai virus or concanavalin A (Con A) to produce IFN-α or IFN-γ, respectively. Pretreatment of leukocytes with any type of IFN enhanced their IFN-α and IFN-γ production, but IFN-α and IFN-β had more potent priming activities than IFN-γ. IFN-α and IFN-γ did not potentiate the priming activity of each other in either the IFN-α- or the IFN-γ-producing system. Pretreatment of leukocytes with relatively high doses of IFN-α or IFN-β (1000 to 3000 IU/ml) resulted in a 40- to 50-fold increase in the IFN-γ production of Con A-stimulated leukocytes. This observation will be of use in producing IFN-γ with a high titre., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-66-4-893