1887

Abstract

SUMMARY

A cytotoxic response to murine cytomegalovirus (MCMV) was obtained by the culture of lymph node cells from mice inoculated with MCMV into both hind footpads 7 days previously. The cytotoxicity was mediated by Thy1.2, Lyt2, H-2-restricted effector cells and was virus-specific. Investigation of the conditions established that T cell proliferation was necessary for optimal generation of cytotoxicity, that proliferation was dependent upon Thy1.2, Lyt2 cell populations and that supernatants from concanavalin A-activated spleen cells enhanced the levels of cytotoxicity obtained.

Keyword(s): cytotoxic T cells , in vitro and MCMV
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/content/journal/jgv/10.1099/0022-1317-66-4-757
1985-04-01
2022-09-30
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