1887

Abstract

SUMMARY

Two distinct groups of influenza A/H3N2 viruses, closely related to A/Bangkok/1/79 and to A/Belgium/2/81, have been chosen from viruses isolated in Italy during 1981 to 1983 with the aim of analysing the biochemical composition of their polypeptides. The strains of each group have shown differences in electrophoretic migration rates in one or more proteins in comparison to the prototype viruses. Polypeptide mobility variations among isolates from circumscribed geographical areas and from single outbreaks have also been observed. In particular, there was a high degree of variability in the NS1 protein. The detection of biochemical differences among identical antigenic variants, probably the result of point mutations in polypeptide sequences or of genetic reassortment among different co-circulating human viruses, is a further expression of the peculiar ability of the influenza A virus to exhibit variation in internal proteins during its circulation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-3-637
1985-03-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/3/JV0660030637.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-3-637&mimeType=html&fmt=ahah

References

  1. Bean W. J., Cox N. J., Kendal A. P. 1980; Recombination of human influenza A viruses in nature. Nature, London 284:638–640
    [Google Scholar]
  2. Brown L. E., Hinshaw V. S., Webster R. G. 1983; Antigenic variation in the influenza A virus non-structural protein, NS1. Virology 130:134–143
    [Google Scholar]
  3. Concepts And Procedures For Laboratory-Based Influenza Surveillance 1982 U.S. Department of Health and Human Services;
  4. De Jong W. W., Zweers A., Cohen L. H. 1978; Influence of single amino acid substitutions on electrophoretic mobility of sodium dodecyl sulfate–protein complexes. Biochemical and Biophysical Research Communications 82:532–539
    [Google Scholar]
  5. Hugentobler A. L., Schild G. C., Oxford J. S. 1981; Differences in the electrophoretic migration rates of polypeptides and RNAs of recent isolates of influenza B viruses. Archives of Virology 69:197–207
    [Google Scholar]
  6. Oxford J. S., Mcgeoch D. J., Schild G. C., Beare A. S. 1978; Analysis of virion RNA segments and polypeptides of influenza A virus recombinants of defined virulence. Nature. London 273:778–779
    [Google Scholar]
  7. Oxford J. S., Schild G. C., Alexandrova G. 1980; Electrophoretic migration rate differences of polypeptides of human influenza A viruses: partial analysis of the genome of influenza vaccine recombinant viruses. Archives of Virology 65:277–291
    [Google Scholar]
  8. Oxford J. S., Corcoran T., Schild G. C. 1981; Intratypic electrophoretic variation of structural and nonstructural polypeptides of human influenza A viruses. Journal of General Virology 56:431–436
    [Google Scholar]
  9. Schild G. C., Oxford J. S., Newman R. W. 1979; Evidence for antigenic variation in influenza A nucleoprotein. Virology 93:569–573
    [Google Scholar]
  10. Van Wyke K. L., Hinshaw V. S., Bean W. J. JR, Webster R. G. 1980; Antigenic variation of influenza A virus nucleoprotein detected with monoclonal antibodies. Journal of Virology 35:24–30
    [Google Scholar]
  11. Young J. F., Palese P. 1979; Evolution of human influenza A viruses in nature: recombination contributes to genetic variation of H1N1 strains. Proceedings of the National Academy of Sciences, U.S.A 76:6547–6551
    [Google Scholar]
  12. Young J. F., Desselberger U., Palese P. 1979; Evolution of human influenza A viruses in nature: sequential mutations in the genome of new H1N1 isolates. Cell 18:73–83
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-3-637
Loading
/content/journal/jgv/10.1099/0022-1317-66-3-637
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error