RT Journal Article SR Electronic(1) A1 Brioen, P. A1 Thomas, A. A. M. A1 Boeyé, A.YR 1985 T1 Lack of Quantitative Correlation between the Neutralization of Poliovirus and the Antibody-mediated pI Shift of the Virions JF Journal of General Virology, VO 66 IS 3 SP 609 OP 613 DO https://doi.org/10.1099/0022-1317-66-3-609 PB Microbiology Society, SN 1465-2099, AB SUMMARY The effect of mono- and polyclonal antibodies on the infectivity and pI (isoelectric pH) of type 1 poliovirus was studied. According to Mandel’s hypothesis, the isoelectric pH of poliovirus should change to about pI 4 upon neutralization. However, several antibodies did not follow this rule. Moreover, when antibodies did shift the pI, no quantitative correlation existed between the extent of neutralization and the amount of poliovirus shifted to low pI., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-66-3-609