1887

Abstract

Summary

The protease inhibitor leupeptin prevented multiplication of the human coronavirus strain 229E in cultures of MRC-C cells. The IC of leupeptin in plaque reduction tests was 0.4 µg/ml, whereas growth of host cells was unaffected by leupeptin at 50 µg/ml. Inhibition of plaque formation could be prevented by the addition of proteases to the overlay medium. In single-cycle growth experiments, leupeptin reduced virus yield only if added within 2 h of infection, indicating its action on an early stage of virus replication.

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/content/journal/jgv/10.1099/0022-1317-66-2-363
1985-02-01
2019-11-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-2-363
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