%0 Journal Article %A Tuffereau, Christine %A Portner, Allen %A Roux, Laurent %T The role of Haemagglutinin-Neuraminidase Glycoprotein Cell Surface Expression in the Survival of Sendai Virus-infected BHK-21 Cells %D 1985 %J Journal of General Virology, %V 66 %N 11 %P 2313-2318 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-66-11-2313 %K Sendai virus %K HN glycoprotein %K cytopathic effect %I Microbiology Society, %X SUMMARY A temperature-sensitive mutant of Sendai virus with a lesion in the haemagglutinin-neuraminidase protein (HN) (ts 271) was used to study the effect of HN cell surface expression on the fate of infected BHK-21 cells. The total amount of HN was reduced in ts 271 virus-infected cells at the non-permissive temperature (38 °C) presumably due to degradation of the protein. At this temperature, neither HN nor a modified form of HN were found expressed at the surface of the infected cells. BHK-21 cells infected with ts 271 were nevertheless killed by the infection at 38 °C as well as at 30 °C. These results ruled out the hypothesis that the lack of HN cell surface expression could be the unique requirement allowing BHK cell survival. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-66-11-2313