1887

Abstract

SUMMARY

A temperature-sensitive mutant of Sendai virus with a lesion in the haemagglutinin-neuraminidase protein (HN) ( 271) was used to study the effect of HN cell surface expression on the fate of infected BHK-21 cells. The total amount of HN was reduced in 271 virus-infected cells at the non-permissive temperature (38 °C) presumably due to degradation of the protein. At this temperature, neither HN nor a modified form of HN were found expressed at the surface of the infected cells. BHK-21 cells infected with 271 were nevertheless killed by the infection at 38 °C as well as at 30 °C. These results ruled out the hypothesis that the lack of HN cell surface expression could be the unique requirement allowing BHK cell survival.

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/content/journal/jgv/10.1099/0022-1317-66-11-2313
1985-11-01
2021-10-22
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