1887

Abstract

SUMMARY

Infection of NMRI mice with increasing doses of six different strains of herpes simplex virus type 1 (HSV-1) induced increasing levels of neutralizing antibodies. In contrast, three strains of HSV-2, irrespective of the dose, induced only marginal antibody responses. Only strain HG 52 (HSV-2) at high doses of infection stimulated antibody formation. The virus content of some organs in 6- to 8-week-old mice appeared to be lower after HSV-2 than after HSV-1 infection. Application of immune-modulating drugs [silica or poly(I).poly(C) coupled via -lysine to CM-cellulose] resulted in little augmentation of antibody formation if compared to HSV-1 infection. Secondary infections with HSV-1 or HSV-2 after a primary dose of HSV-1 were followed by a marked booster response. In contrast, a primary infection with HSV-2 suppressed secondary responses of HSV-1 and HSV-2, thus indicating fundamental differences between the antibody-stimulating potency of HSV-1 and HSV-2 strains.

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1985-10-01
2022-01-28
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References

  1. Allison A. C., Harington J. S., Birbeck M. 1966; An examination of the cytotoxic effects of silica on macrophages. Journal of Experimental Medicine 124:141–154
    [Google Scholar]
  2. Andonov P., Dundarov S., Bakalov B., Tomov S., Zenov N., Todorova R. 1978; The effect of killed antiherpes vaccines. International Congress on Infectious and Parasitic Diseases (Varna, Bulgaria): p 538
    [Google Scholar]
  3. Brown S. M., Ritchie D. A., Subak-Sharpe J. H. 1973; Genetic studies with herpes simplex type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. Journal of General Virology 18:329–346
    [Google Scholar]
  4. Bürfent I. 1979 Untersuchungen zur Gewinnung von temperatursensiblen Mutanten bei Herpes simplex Virus Typ 2 Inaugural dissertation Bonn, F.R.G;
    [Google Scholar]
  5. Caspary L., Schindling B., Dundarov S., Falke D. 1980; Infections of susceptible and resistant mouse strains with herpes simplex virus type 1 and 2. Archives of Virology 65:219–227
    [Google Scholar]
  6. Champney K. G., Levine D. P., Levy H. B., Lerner A. M. 1979; Modified polyriboinosinic-polyribocytidylic acid complex: sustained interferonemia and its physiological associates in humans. Infection and Immunity 25:831–837
    [Google Scholar]
  7. Diamantstein T., Rühl H., Vogt W., Bochert G. 1973; Stimulation of B-cells by dextran sulphate in vitro. Immunology 25:743–747
    [Google Scholar]
  8. Diamantstein T., Blitstein-Willinger E., Schulz G. 1974; Polyanions and lipopolysaccharide acts on different subpopulations of B cells. Nature, London 250:596–597
    [Google Scholar]
  9. Friedman R. M., Vogel S. N. 1983; Interferons with special emphasis on the immune system. Advances in Immunology 34:97–137
    [Google Scholar]
  10. Göertz J., Brake B., Härle-Grupp V., Falke D. 1984; Replication of HSV-1 in murine peritoneal macrophages: comparison of various virus strains with different properties. Archives of Virology 79:173–187
    [Google Scholar]
  11. Halliburton I. W., Timbury M. C. 1976; Temperature-sensitive mutants of herpes simplex virus type 2: description of three new complementation groups and studies on the inhibition of host cell DNA synthesis. Journal of General Virology 30:207–221
    [Google Scholar]
  12. Hilleman M. 1979; Herpes simplex subunit vaccine. In Experimental Herpes Virus Vaccine Workshop (1979), pp 427–444 Bethesda: FDA, Bureau of Biologies, National Cancer Institute, NIAID;
    [Google Scholar]
  13. Humes J. L., Bonney R. J., Pelus L., Dahlgren M. E., Sadowski S. J., Kuehl F. A. Jr, Davies P. 1977; Macrophages synthesise and release prostaglandins in response to inflammatory stimuli. Nature, London 269:149–151
    [Google Scholar]
  14. Ishizuka M., Umezawa H. 1983; Effect of bestatin on experimental animal tumors. In Proceedings of the XIII International Congress on Chemotherapy (Wien, 1983) 204/3–204/8
    [Google Scholar]
  15. Iwasaka T., Sheridan J. F., Aurelian L. 1983; Immunity to herpes simplex virus type 2: recurrent lesions are associated with the induction of suppressor cells and soluble factors. Infection and Immunity 42:955–964
    [Google Scholar]
  16. Johnson H. M. 1981; Effect of interferon on antibody formation. Texas Reports on Biology and Medicine 41:411–419
    [Google Scholar]
  17. Kaerner H. C., Schröder C. H., Ott-Hartmann A., Kümel G., Kirchner H. 1983; Genetic variability of HSV: development of a pathogenic variant during passaging of a non-pathogenic HSV-1 virus strain in mouse brain. Journal of Virology 46:83–93
    [Google Scholar]
  18. Kirchner H., Hirt H. M., Kleinicke C., Munk K. 1976; Replication of herpes simplex virus in mouse spleen cell cultures stimulated by lipopolysaccharide. Journal of Immunology 117:1753–1756
    [Google Scholar]
  19. Knoblich A. 1984 Die Antikorperbildung der mit Herpes simplex virus Typ I primar infizierten Maus Inaugural dissertation Mainz, F.R.G;
    [Google Scholar]
  20. Knoblich A., Göertz J., Härle-Grupp V., Falke D. 1983a; Kinetics and genetics of herpes simplex virus-induced antibody formation in mice. Infection and Immunity 39:15–23
    [Google Scholar]
  21. Knoblich A., Kampe P., Härle-Grupp V., Falke D. 1983b; Aspects of regulation of antibody formation against HSV-1 and 2 in the mouse. Abstracts, VIIIth International Workshop on Herpesviruses (Oxford, U,. K.): p 81.
    [Google Scholar]
  22. Knoblich A., Müller W. E. G., Härle-Grupp V., Falke D. 1984; Enhancement of antibody formation against herpes simplex virus in mice by the T-cell mitogen bestatin. Journal of Genera! Virology 65:1675–1686
    [Google Scholar]
  23. McGeorge M. B., Morahan P. S. 1978; Comparison of various macrophage-inhibitory agents on vaginal and systemic herpes simplex virus type 2 infections. Infection and Immunity 22:623–626
    [Google Scholar]
  24. Martinez D., Lynch R. G., Meeker G. B., Field A. K. 1980; Macrophage dependence of polyriboinosinic acid-polyribocytidylic acid-induced resistance to HSV infection in mice. Infection and Immunity 28:147–153
    [Google Scholar]
  25. Metzger Z., Hoffeld J. T., Oppenheim J. J. 1980; Macrophage-mediated suppression. I. Evidence for participation of both hydrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation. Journal of Immunology 124:983–988
    [Google Scholar]
  26. Morahan P. S., Breinig M. C., McGeorge M. B. 1977; Immune responses to vaginal or systemic infection of BALB/c mice with herpes simplex virus type 2. Journal of Immunology 119:2030–2036
    [Google Scholar]
  27. Müller W. E. G., Schuster D. K., Zahn R. K., Maidhof A., Leyhausen G., Falke D., Koren R., Umezawa H. 1982; Properties and specificity of binding sites for the immunomodulator bestatin on the surface of mammalian cells. International Journal of Immunopharmacology 4:393–400
    [Google Scholar]
  28. Nash A. A., Gell P. G. H. 1980; Cell-mediated immunity in herpes simplex virus-infected mice: suppression of delayed hypersensitivity by an antigen-specific B lymphocyte. Journal of General Virology 48:359–364
    [Google Scholar]
  29. Pelton P. K., Duncan B., Denman A. 1980; Herpes simplex virus depresses antibody production by affecting T-cell functions. Nature, London 284:176–177
    [Google Scholar]
  30. Rawls W. E., Tompkins W. A. F., Figueroa M. F., Melnick J. L. 1968; Herpesvirus type 2: association with carcinoma of the cervix. Science 161:1255–1256
    [Google Scholar]
  31. Röllinghoff M., Starzinski-Powitz A., Pfitzenmaier K., Wagner H. 1977; Cyclophosphamide sensitive T-lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T-lymphocytes. Journal of Experimental Medicine 145:455–459
    [Google Scholar]
  32. Rühl H., Vogt W., Bochert G., Diamantstein T. 1974; Stimulation of B cells by poly A:poly U and poly I: poly C in vitro. Immunology 26:937–941
    [Google Scholar]
  33. Schroder C. H., Engler M., Kirchner H. 1981; Protection of mice by an apathogenic strain of HSV-1 against lethal infection by a pathogenic strain of HSV-1. Journal of General Virology 52:159–161
    [Google Scholar]
  34. Shek P. N., Coons A. H. 1978; Effect of colchicine on the antibody response. I. Enhancement of antibody formation in mice. Journal of Experimental Medicine 147:1213–1227
    [Google Scholar]
  35. Shek P. N., Waltenbauch C., Coons A. H. 1978; Effect of colchicine on the antibody response. II. Demonstration of the inactivation of suppressor cell activities by colchicine. Journal of Experimental Medicine 147:1228–1235
    [Google Scholar]
  36. Stebbing N., Lindley J. D., Dawson K. M. 1980; Variations in the contribution of induced interferon and adjuvanticity of the antiviral effect of different polyinosinic acid: polycytidylic acid formulations in mice infected with encephalomyocarditis virus. Infection and Immunity 29:960–965
    [Google Scholar]
  37. Thouless M. E. 1972; Serological properties of thymidine kinase produced in cells infected with type 1 or type 2 herpes virus. Journal of General Virology 17:307–315
    [Google Scholar]
  38. Worthington M., Conliffe M. A., McGregor A., Baron S. 1980; Mechanism of recovery from systemic herpes simplex virus infection. I. Comparative effectiveness of antibody and reconstitution of immune spleen cells on immunosuppressed mice. Journal of Infectious Diseases 142:163–174
    [Google Scholar]
  39. Zisman B., Hirsch M. S., Allison A. C. 1970; Selective effects of anti-macrophage serum, silica and antilymphocyte serum on pathogenesis of herpes virus infection of young adult mice. Journal of Immunology 104:1155–1159
    [Google Scholar]
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