The late region of bovine papillomavirus type 2 (BPV-2) DNA has been identified. The complete nucleotide sequence of the region was determined and revealed two large open reading frames. The DNA sequence results and the predicted amino acid sequence of putative polypeptides encoded by this region are presented. Comparative analysis of the BPV-2 late region and the corresponding area of BPV-1 was performed. This study demonstrates that identical genetic organization and considerable nucleotide sequence conservation exists between these two serotypes.
CampoM. S.,
CogginsL. W.1982; Molecular cloning of bovine papillomavirus genomes and comparison of their sequence homologies by heteroduplex mapping. Journal of General Virology 63:255–264
ChenE. Y.,
HowleyP. M.,
LevinsonA. D.,
SeeburgP. H.1982; The primary structure and genetic organization of the bovine papillomavirus type 1 genome. Nature, London 299:529–534
DanosO.,
KatinkaM.,
YanivM.1982; Human papillomavirus la complete DNA sequence: a novel type of genome organization among Papovaviridae. EMBO Journal 1:231–236
DanosO.,
EngelL. W.,
ChenE. Y.,
YanivM.,
HowleyP. M.1983; Comparative analysis of the human type la and bovine type 1 papillomavirus genomes. Journal of Virology 46:557–566
KushnerS. R.1978; An improved method for transformation of Escherichia coli with Col El derived plasmids. In Genetic Engineering pp 17–23 Edited by
BoyerH. B.,
NicosiaS.
Amsterdam: Elsevier/North-Holland;
LawM. F.,
LowyD. R.,
DvoretzkyI.,
HowleyP. M.1981; Mouse cells transformed by bovine papillomavirus DNA sequences. Proceedings of the National Academy of Sciences, U.S.A 78:2727–2731
LowyD. R.,
DvoretzkyL.,
ShoberR.,
LawM. F.,
EngelL.,
HowleyP. M.1980; In vitro tumorigenic transformation by a defined subgenomic fragment of bovine papilloma virus DNA. Nature, London 287:72–74
ManiatisT.,
FritschE. F.,
SambrookJ.1982; Isolation of bacteriophage X and plasmid DNA. In Molecular Cloning, A Laboratory Manual pp 75–96 New York: Cold Spring Harbor Laboratory;
MeinkeW.,
MeinkeG. C.1981; Isolation and characterization of the major capsid protein of bovine papilloma virus type 1. Journal of General Virology 52:15–24
MoarM. H.,
CampoM. S.,
LairdH.,
IarrettW. F. H.1981; Persistence of nonintegrated viral DNA in bovine cells transformed in vitro by bovine papillomavirus type 2. Nature, London 293:749–751
PfisterH.,
LinzV.,
GissmanL.,
HuchthausenB.,
HoffmannD.,
Zur HausenH.1979; Partial characterization of a new type of bovine papilloma virus. Virology 96:1–8
PotterH. L.,
MurphyM. F.,
AbrahamJ. M.,
MorganD. M.,
MeinkeW. M.1981; Analysis of a restriction endonuclease map for bovine papillomavirus type 2 DNA. Bioscience Reports 1:229–234
StenlundA.,
Moreno-LopezJ.,
AholaH.,
PetterssonU.1983; European elk papillomavirus: characterization of the genome, induction of tumors in animals, and transformation in vitro. Journal of Virology 48:370–376