1887

Abstract

Summary

Using immunocytochemical procedures in conjunction with electron microscopy we have examined the distribution of the major DNA-binding protein (DBP) of herpes simplex virus (HSV) in infected nuclei. In embedded specimens, DBP was preferentially associated with fibrillar material of electron-translucent viral inclusions, and to a lesser extent with peripheral (marginated) host chromatin. The latter association was sensitive to a non-ionic detergent (‘Photo flo’). In chromatin spread by the Miller technique, DBP was found to be a component of the 10 nm ‘thick filaments’ previously described in HSV infection.

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/content/journal/jgv/10.1099/0022-1317-66-1-15
1985-01-01
2019-11-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-1-15
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