@article{mbs:/content/journal/jgv/10.1099/0022-1317-65-9-1487, author = "Ohmann, H. Bielefeldt and Gilchrist, J. E. and Babiuk, L. A.", title = "Effect of Recombinant DNA-produced Bovine Interferon Alpha (BoIFN-α1) on the Interaction between Bovine Alveolar Macrophages and Bovine Herpesvirus Type 1", journal= "Journal of General Virology", year = "1984", volume = "65", number = "9", pages = "1487-1495", doi = "https://doi.org/10.1099/0022-1317-65-9-1487", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-65-9-1487", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "BHV-1", keywords = "alveolar macrophages", keywords = "interferon (BoIFN-α1)", abstract = "SUMMARY Treatment of bovine alveolar macrophages (BAM) with bovine leukocyte interferon (BoIFN-α1) resulted in reduced bovine herpesvirus type 1 replication and spread. This was demonstrated by reduced virus yields and number of cells infected. BoIFN-α1 treatment of BAM also induced enhanced Fc receptor expression and/or avidity by the cells, increased their activity in antibody-dependent cellular cytotoxicity, and augmented their extrinsic antiviral activity as measured by a reduction in the development of plaques in a susceptible cell line. These results are discussed in the context of the possible role of interferon in activation of AM during the early phases of a virus infection.", }