1887

Abstract

SUMMARY

Zosteriform spread of herpes simplex virus (HSV) infection occurs after primary inoculation of the skin of both outbred and inbred mice. With HSV type 1 strain SC16 few outbred animals died if they were inoculated when 8 weeks old whereas up to 50% of animals died if inoculated when 4 weeks old. However, at either age, zosteriform spread of infection occurred in almost all animals as it did when 4-week-old outbred animals were inoculated with the avirulent strain KOS. Thus, control of zosteriform spread must act by different mechanisms from those controlling the encephalitis which leads to death. During replication in the epidermis virus enters axons and could first be found in sensory ganglia 2 days after inoculation of the skin. Thereafter, it was found in the nerve roots and in skin within the same dermatome but remote from the site of inoculation. When sensory nerves to this latter area were cut during the 4 days after primary inoculation lesions developing as a result of zosteriform spread were either completely inhibited or, with later section, decreased in incidence. Mortality was not affected by such nerve section. Latent infection must be established in neurons serving areas of skin remote from the inoculation site since with HSV-1 strain SC16, recrudescent lesions on the pinna could be induced by stripping the skin of the ear when the original inoculation had been in the skin of the neck. Such recrudescent disease was not demonstrated in animals infected with HSV-1 strain KOS even though this virus efficiently established latent infection in sensory ganglia.

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1984-09-01
2022-10-02
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References

  1. Baringer I. R. 1975; Herpes simplex virus infection of nervous tissue in animals and man. Progress in Medical Virology 20:1–26
    [Google Scholar]
  2. Constantine V. S., Francis R. D., Mason B. H. 1971; Experimental zoster-like herpes simplex in hairless mice. Journal of Investigative Dermatology 56:193–199
    [Google Scholar]
  3. Cook M. L., Stevens J. G. 1973; Pathogenesis of herpetic neuritis and ganglionitis: evidence for intra-axonal transport of infection. Infection and Immunity 7:272–288
    [Google Scholar]
  4. Corey L. 1984; Natural history of genital HSV infection. In ‘Herpesvirus’ UCLA Symposia on Molecular and Cellular Biology, New Series vol 21: Edited by Rapp F. New York: Alan R. Liss; (in press)
    [Google Scholar]
  5. Darville J. M., Blyth W. A. 1982; Neutralizing antibody in mice with primary and recurrent herpes simplex virus infection. Archives of Virology 71:303–310
    [Google Scholar]
  6. Dillard S. H., Cheatham W. J., Moses H. L. 1972; Electron microscopy of zosteriform herpes simplex infection in the mouse. Laboratory Investigation 26:391–402
    [Google Scholar]
  7. Goodpasture E. W. 1929; Herpetic infection with special reference to involvement of the nervous system. Medicine 8:223–243
    [Google Scholar]
  8. Goodpasture E. W., Teague O. 1923; Transmission of the virus of herpes febrilis along nerves in experimentally infected rabbits. Journal of Medical Research 44:139–184
    [Google Scholar]
  9. Harbour D. A., Hill T. J., Blyth W. A. 1983; Recurrent herpes simplex in the mouse: inflammation in the skin and activation of virus in the ganglia following peripheral stimulation. Journal of General Virology 64:1491–1498
    [Google Scholar]
  10. Hill T. J. 1983; Herpesviruses in the central nervous system. In Viruses and Demyelinating Diseases pp 29–45 Edited by Mims C. A. New York: Academic Press;
    [Google Scholar]
  11. Hill T. J. 1984; Herpes simplex virus latency. In The Herpesviruses vol 3: Edited by Roizman B. New York: Plenum Press; (in press)
    [Google Scholar]
  12. Hill T. J., Field H. J., Blyth W. A. 1975; Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28:341–353
    [Google Scholar]
  13. Hill T. J., Blyth W. A., Harbour D. A. 1978; Trauma to the skin causes recurrence of herpes simplex in the mouse. Journal of General Virology 39:21–28
    [Google Scholar]
  14. Hill T. J., Blyth W. A., Harbour D. A. 1982; Recurrent herpes simplex in mice: topical treatment with acyclovir cream. Antiviral Research 2:135–146
    [Google Scholar]
  15. Hill T. J., Blyth W. A., Harbour D. A., Berrie E. L., Tullo A. B. 1983a; Latency and other consequences of infection of the nervous system with herpes simplex virus. Progress in Brain Research 59:173–184
    [Google Scholar]
  16. Hill T. J., Blyth W. A., Harbour D. A. 1983b; Recurrence of herpes simplex in the mouse requires an intact nerve supply to the skin. Journal of General Virology 64:2763–2765
    [Google Scholar]
  17. Hill T. J., Blyth W. A., Harbour D. A., Tullo A. B., Easty D. L., Shimeld C. 1984; Antiviral agents, antiinflammatory agents and models of herpes simplex in the mouse. In Herpesvirus UCLA Symposia on Molecular and Cellular Biology, New Series vol 2: Edited by Rapp F. New York: Alan R. Liss; (in press)
    [Google Scholar]
  18. Knotts F. B., Cook M. L., Stevens J. G. 1974; Pathogenesis of herpetic encephalitis in mice following ophthalmic inoculation. Journal of Infectious Diseases 130:16–27
    [Google Scholar]
  19. Mok C. H. 1971; Zoster-like disease in infants and young children. New England Journal of Medicine 285:294
    [Google Scholar]
  20. Music S. I., Fine E. M., Togo Y. 1971; Zoster-like disease in the newborn due to herpes simplex virus. New England Journal of Medicine 284:20–24
    [Google Scholar]
  21. Nash A. A., Quartey-Papafio R., Wildy P. 1980; Cell mediated immunity in herpes simplex virus-infected mice: functional analysis of lymph node cells during periods of acute and latent disease, with reference to cytotoxic and memory cells. Journal of General Virology 49:309–317
    [Google Scholar]
  22. Robinson T. W. E., Dover J. R. 1972; Experimental zosteriform herpes simplex virus infection in mouse skin. British Journal of Dermatology 86:40–48
    [Google Scholar]
  23. Stanberry L. R., Kern E. R., Richards J. T., Abbott T. M., Overall J. C. 1982; Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. Journal of Infectious Diseases 146:397–404
    [Google Scholar]
  24. Sydiskis R. J., Schultz L. 1965; Herpes simplex skin infection in mice. Journal of Infectious Diseases 115:237–246
    [Google Scholar]
  25. Tanaka S., Southam C. M. 1965; Zoster-like lesions from herpes simplex virus in newborn rats. Proceedings of the Society for Experimental Biology and Medicine 120:56–59
    [Google Scholar]
  26. Teague O., Goodpasture E. W. 1923; Experimental herpes zoster. Journal of Medical Research 44:185–200
    [Google Scholar]
  27. Townsend J. J., Baringer J. R. 1976; Comparative vulnerability of peripheral and central nervous tissue to herpes simplex virus. Journal of Neuropathology and Experimental Neurology 35:100
    [Google Scholar]
  28. Townsend J. J., Baringer J. R. 1978; Central nervous system susceptibility to herpes simplex infection. Journal of Neuropathology and Experimental Neurology 37:255–262
    [Google Scholar]
  29. Tullo A. B., Shimeld C., Blyth W. A., Hill T. J., Easty D. L. 1982a; Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse. Journal of General Virology 63:95–101
    [Google Scholar]
  30. Tullo A. B., Easty D. L., Hill T. I., Blyth W. A. 1982b; Ocular herpes simplex and the establishment of latent infection. Transactions of the Ophthalmological Society of the United Kingdom 102:15–18
    [Google Scholar]
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