1887

Abstract

SUMMARY

Treatment of scrapie-infected mice with dextran sulphate (DS) 500 resulted in considerably reduced spleen titres over a long period of time. Subsequently, the central nervous system disease was delayed or even prevented during the 350-day period of observation. Both effects increased after multiple injections of the compound. The potency of DS 500 to protect against scrapie was greatest when treatment and infection were carried out simultaneously. Under these conditions the lethality of 500 to 1000 LD was reduced to almost zero. Treatment as early as 10 weeks before infection still prolonged the incubation periods. Of several other polyions tested, dextran sulphate 5 and pentosan polysulphate also impaired scrapie pathogenesis.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-65-8-1325
1984-08-01
2022-01-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/65/8/JV0650081325.html?itemId=/content/journal/jgv/10.1099/0022-1317-65-8-1325&mimeType=html&fmt=ahah

References

  1. Ehlers B. 1983 Scrapie – Pathogenetische Untersuchungen bei der Maus Thesis for the degree of doctor of veterinary medicine Freie Universitӓt Berlin;
    [Google Scholar]
  2. Ehlers B., Rudolph R., Diringer H. 1984; The reticuloendothelial system in scrapie pathogenesis. Journal of General Virology 65:423–428
    [Google Scholar]
  3. Gibbs C. J., Gajdusek D. C. 1978; Atypical viruses as the cause of sporadic, epidemic and familial chronic diseases in man: slow viruses and human diseases. Perspectives in Virology 10:161–198
    [Google Scholar]
  4. Kimberlin R. H. 1976; Experimental scrapie in the mouse: a review of an important model disease. Scientific Progress 63:461–481
    [Google Scholar]
  5. Kimberlin R. H., Walker C. A. 1978; Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. Journal of Comparative Pathology 88:39–47
    [Google Scholar]
  6. Kimberlin R. H., Walker C. A. 1979; Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. Journal of Comparative Pathology 89:551–562
    [Google Scholar]
  7. Kimberlin R. H., Walker C. A. 1983; The antiviral compound HPA-23 can prevent scrapie when administered at the time of infection. Archives of Virology 78:9–18
    [Google Scholar]
  8. Schafer W. 1979; Der Mause-Inzuchtstamm STU, Entwicklung und Eigenschaften. Zeitschrift fur Naturforschung 34c:306–309
    [Google Scholar]
  9. Streitberg B., Rӧhmel J. 1983; Exakte Verteilungen für Rang- und Randomisierungstests im allgemeinen C- Stichprobenproblem. Tagung der International Biometric Society, Sektion Deutschland, Frühjahr 1983
    [Google Scholar]
  10. Walton K. W. 1954; Investigation of the toxicity of a series of dextran sulphates of varying molecular weight. British Journal of Pharmacology 9:1–14
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-8-1325
Loading
/content/journal/jgv/10.1099/0022-1317-65-8-1325
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error