1887

Abstract

Summary

Swiss mice immunized with formalin-inactivated encephalomyocarditis virus (EMCV) produced antibodies to EMCV and were protected when infected intraperitoneally with EMCV. Administration of a potent sheep anti-mouse interferon-α/β (IFN-α/β) globulin before reinfection did not alter the vaccine-induced protection. Reinfection was associated with a rapid disappearance of the virus at the site of injection and viraemia was not demonstrable. IFN was not detected in the peritoneum or serum. Furthermore, injection of anti-IFN globulin before, during or after vaccination did not modify the humoral response to vaccination or to reinfection. These results indicate that IFN-α/β does not play a significant role in the resistance of mice to reinfection with EMCV.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-65-7-1203
1984-07-01
2019-11-17
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-7-1203
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error