1887

Abstract

For the sake of brevity, I shall confine this review to the inactivation of virus infectivity which is the direct result of combination with neutralizing antibody. This restriction is solely for convenience and is not intended as a judgement of the importance of neutralization versus inactivation involving secondary factors such as complement or cells which interact with antibodies.

Neutralizing antibody is one of the main arms of protective immunity and is the type of immunity which usually results from vaccination, so it is somewhat surprising to find that we understand little of the interaction between neutralizing antibody and antigenic determinants of the virus, and how as a result infectivity is lost. In fact, the situation is worse than mere ignorance and it is probably not overstating the case to say that in the past the dogma of neutralization has been based on a logical fallacy.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-65-6-1015
1984-06-01
2019-12-09
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-6-1015
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error